Natural products as mediators of disease.
Natural products as mediators of disease.
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DOI：
10.1039/c6np00063k
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发表时间：
2017-02-01
影响因子：
11.9
通讯作者：
Phelan VV
中科院分区：
文献类型：
--
作者：
Garg N;Luzzatto-Knaan T;Melnik AV;Caraballo-Rodríguez AM;Floros DJ;Petras D;Gregor R;Dorrestein PC;Phelan VV
人类正在行走的微生物生态系统，每个都有一个复杂的微生物群，具有产生大量天然产品的遗传潜力。最近的测序数据表明，我们的微生物栖息地对维持整体健康至关重要。微生物群落的变化与许多疾病有关，包括感染、炎症、癌症和神经疾病。其中一些临床和诊断相关的表型是小分子存在的结果，但我们对它们对个人健康的贡献知之甚少。在这里，我们回顾了微生物衍生的天然产物作为人类疾病的媒介。
Humans are walking microbial ecosystems, each harboring a complex microbiome with the genetic potential to produce a vast array of natural products. Recent sequencing data suggest that our microbial inhabitants are critical for maintaining overall health. Shifts in microbial communities have been correlated to a number of diseases including infections, inflammation, cancer, and neurological disorders. Some of these clinically and diagnostically relevant phenotypes are a result of the presence of small molecules, yet we know remarkably little about their contributions to the health of individuals. Here, we review microbe-derived natural products as mediators of human disease.