The use of antibiotic-containing bead chains in the treatment of chronic bone infections
The use of antibiotic-containing bead chains in the treatment of chronic bone infections
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DOI：
10.1046/j.1469-0691.2001.00186.x
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发表时间：
2001-01-01
影响因子：
14.2
通讯作者：
Klemm, K
中科院分区：
文献类型：
--
作者：
Klemm, K
将庆大霉素聚甲基丙烯酸甲酯 (PMMA) 链或小链植入感染的骨髓腔中是一种行之有效的局部抗生素疗法，可补充根治性清创术。感染部位的庆大霉素浓度远高于慢性骨髓炎最常见病原体的 MIC。血清和尿液浓度较低，不用担心这种庆大霉素应用会产生肾毒性和耳毒性副作用。在使用庆大霉素 PMMA 链的局部抗生素治疗下，可以预期像无菌手术中那样的初级伤口愈合。不需要长期全身抗生素治疗。在一系列405例中，获得了90.4%的成功率。
The implantation of gentamicin polymethylmethacrylate (PMMA) chains or minichains into infected osteomyelitic cavities is a well-established local antibiotic therapy supplementary to radical debridement. The gentamicin concentrations achieved at the site of infection are far above the MICs for most common pathogens in chronic osteomyelitis. Serum and urine concentrations are low and nephrotoxic and ototoxic side-effects of this form of gentamicin application are not to be feared. Under local antibiotic therapy with gentamicin PMMA chains, primary wound healing as in aseptic surgery can be expected. Prolonged systemic antibiotic therapy is unnecessary. In a series of 405 cases, a success rate of 90.4% was obtained.