Toxicology of ipecac: a review.
Toxicology of ipecac: a review.
复制标题
吐根毒理学：综述。
作者：
B. Manno;J. E. Manno
吐根糖浆本身的一般有效性和安全性没有受到质疑，而是试图巩固有关吐根液提取物毒性表现的相关文献。吐根含有艾美汀和头孢林，吐根液提取物的毒性与这两种化合物的毒性报告一致。大部分工作涉及到艾美汀，因为它在吐根液提取物中的浓度高于头孢林。通过对吐根糖浆或液体提取物中过量使用的临床表现与阿米巴病治疗中艾美汀毒性的比较，我们可以总结出吐根生物碱毒性的一般特征，主要涉及胃肠道、心血管和神经肌肉病灶。
The general effectiveness and safety of Ipecac syrup, per se, has not been questioned, but rather an attempt has been made to consolidate pertinent literature dealing with the toxic manifestations of Ipecac fluid extract. Ipecac contains both emetine and cephaeline and the toxicity of Ipecac fluid extract is consistent with reports on the toxicity of both compounds. The majority of the work has involved emetine since it is in higher concentration in Ipecac fluid extract than is cephaeline. Comparison of the clinical picture presented in syrup or fluid extract of Ipecac overdose and emetine toxicity in amebiasis treatment permits us to summarize the general characteristics of Ipecac alkaloid toxicity as involving primarily gastrointestinal, cardiovascular, and neuromuscular foci.