Voluntary Running Suppresses Proinflammatory Cytokines and Bone Marrow Endothelial Progenitor Cell Levels in Apolipoprotein-E-Deficient Mice
Voluntary Running Suppresses Proinflammatory Cytokines and Bone Marrow Endothelial Progenitor Cell Levels in Apolipoprotein-E-Deficient Mice
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DOI：
10.1089/ars.2008.2092
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发表时间：
2009-01-01
影响因子：
6.6
通讯作者：
Yan, Zhen
中科院分区：
文献类型：
--
作者：
Ajijola, Olujimi A.;Dong, Chunming;Yan, Zhen
长期运动与减少动脉粥样硬化负担、炎症和提高小鼠内皮祖细胞(EPC)水平有关。在小鼠体内输注祖细胞可以减少动脉粥样硬化并抑制炎症。这项研究的目的是确定运动诱导的内皮祖细胞增强是否与动脉粥样硬化和炎症的减少有关。为了研究这一点，20周龄的ApoE(-/-)小鼠患有晚期动脉粥样硬化病变(n=12/组)，随机分为自愿跑步和不跑步8周。运动可有效抑制循环中升高的促炎细胞因子，但不能显著减少动脉粥样硬化病变。在早期动脉粥样硬化性疾病的载脂蛋白E(-/-)小鼠中重复进行锻炼，可导致主动脉根部病变厚度(内膜/中层比率)减少62%(p=0.017)。有趣的是，在ApoE(-/-)小鼠的促炎条件下，BM-EPC水平显著升高，并随着运动的反应而降低，与动脉粥样硬化的程度无关。在早期动脉粥样硬化的情况下，长期运动可以减轻动脉粥样硬化斑块的负担，并与减少全身炎症有关。动脉粥样硬化条件下BM-EPC的升高可能是全身血管炎症或损伤的标志，运动后反应减弱，与其他炎症标志一起。抗氧化剂。氧化还原信号。11，15-23。
Long-term exercise is associated with reduced atherosclerotic burden, inflammation, and enhanced endothelial progenitor cell (EPC) levels in mice. Infusion of progenitor cells in mice decreases atherosclerosis and suppresses inflammation. The aim of this study was to determine whether exercise-induced enhancement of EPCs is associated with reduced atherosclerosis and inflammation. To study this, 20-week old ApoE(-/-) mice with advanced atherosclerotic lesions (n = 12/group) were randomized to voluntary running or no running for 8 weeks. Exercise led to a potent suppression of elevated circulating proinflammatory cytokines without significant reduction of atherosclerotic lesions. When repeated in ApoE(-/-) mice with early atherosclerotic disease, exercise led to a 62% (p = 0.017) reduction in lesion thickness (intima-to-media ratio) at the aortic root. Interestingly, BM-EPC levels were significantly elevated under proinflammatory conditions seen in ApoE(-/-) mice and decreased in response to exercise, independent of the degree of atherosclerosis. Under early atherosclerotic conditions, long-term exercise reduces atherosclerotic plaque burden and is associated with reduced systemic inflammation. Elevated BM-EPCs seen in atherosclerotic conditions may be a marker of generalized vascular inflammation or injury, and decrease in response to exercise, along with other markers of inflammation. Antioxid. Redox Signal. 11, 15-23.