Retinal and cochlear toxicity of drugs: new insights into mechanisms and detection.
Retinal and cochlear toxicity of drugs: new insights into mechanisms and detection.
复制标题
药物的视网膜和耳蜗毒性：机制和检测的新见解。
DOI：
10.1097/wco.0b013e32834ed882
复制
发表时间：
2012
影响因子：
4.8
通讯作者：
Warchol,MarkE
中科院分区：
文献类型：
--
作者：
Audo,Isabelle;Warchol,MarkE
实验和临床研究已经阐明了视网膜毒性和耳毒性的一些致病机制、过程和危险因素，并建立了相关的监测方案。然而，进一步的研究需要更好地了解导致变性的细胞途径。这将有助于建立更有效的预防性干预措施，也可能有助于了解遗传疾病等其他退化过程。
Experimental and clinical studies have elucidated some of the pathogenic mechanisms, courses and risk factors of retinal toxicity and ototoxicity, which have led to establishment of relevant monitoring protocols. Further studies are, however, warranted to better understand cellular pathways leading to degeneration. These would help to build more efficient preventive intervention and may also contribute to understanding of other degenerative processes such as genetic disorders.