Expect the unexpected: conventional and unconventional roles for cadherins in collective cell migration
Expect the unexpected: conventional and unconventional roles for cadherins in collective cell migration
复制标题
期待意想不到的事情：钙粘蛋白在集体细胞迁移中的传统和非常规作用
DOI：
10.1042/bst20221202
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发表时间：
2023
影响因子：
3.9
通讯作者：
McDonald, Jocelyn A.
中科院分区：
文献类型：
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作者：
Messer, C. Luke;McDonald, Jocelyn A.
迁移细胞群体在正常发育期间和在病理学背景（例如肿瘤侵袭和转移）中导航复杂的组织环境。要做到这一点，集体中的细胞必须保持在一起，但也要在整个群体中传达信息。钙粘蛋白超家族的蛋白质介导细胞之间的连接粘附，但也在集体细胞迁移中发挥许多重要功能。除了保持迁移的细胞群体的凝聚力，钙粘蛋白还帮助跟随细胞保持它们对领导细胞的附着，在队列中传递关于前后极性的信息，感知和响应组织环境的变化，并促进细胞内信号传导，以及其他细胞行为。在这篇综述中，我们强调了最近的研究，揭示了不同的，但关键作用的经典和非典型的钙粘蛋白在集体细胞迁移，特别是集中在四个体内模型系统的发展：果蝇的细胞，斑马鱼中内胚层细胞，果蝇滤泡旋转，和Xenopus神经嵴细胞。
Migrating cell collectives navigate complex tissue environments both during normal development and in pathological contexts such as tumor invasion and metastasis. To do this, cells in collectives must stay together but also communicate information across the group. The cadherin superfamily of proteins mediates junctional adhesions between cells, but also serve many essential functions in collective cell migration. Besides keeping migrating cell collectives cohesive, cadherins help follower cells maintain their attachment to leader cells, transfer information about front-rear polarity among the cohort, sense and respond to changes in the tissue environment, and promote intracellular signaling, in addition to other cellular behaviors. In this review, we highlight recent studies that reveal diverse but critical roles for both classical and atypical cadherins in collective cell migration, specifically focusing on fourin vivomodel systems in development: theDrosophilaborder cells, zebrafish mesendodermal cells,Drosophilafollicle rotation, andXenopusneural crest cells.