Molecular signatures of metastasis in head and neck cancer
Molecular signatures of metastasis in head and neck cancer
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DOI：
10.1002/hed.20871
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发表时间：
2008-10-01
影响因子：
2.9
通讯作者：
Krahe, Ralf
中科院分区：
文献类型：
--
作者：
Colella, Stefano;Richards, Kristy L.;Krahe, Ralf
背景转移是癌症治疗失败和死亡的主要原因，但转移机制仍不完全清楚。方法.我们通过对来自27例患者的70个样本进行转录谱分析，研究了头颈癌转移的分子基础，这些样本与正常邻近组织、原发肿瘤和颈部淋巴结转移相匹配。结果我们鉴定了原发性肿瘤和转移瘤共同的肿瘤相关表达特征。匹配转移的使用揭示了另外46个失调基因仅与头颈癌转移相关。然而，尽管在我们的样本集中是转移特异性的，但这46个基因与先前在转移的原发性肿瘤中发现的基因一致。结论.尽管我们的数据和相关研究表明，大部分转移潜能似乎是原发性肿瘤所固有的，但它们也与以下概念一致，即产生最终转移细胞所需的额外克隆变化数量有限，尽管时间顺序可变。(C)2008年，Wiley期刊。
Background. Metastases are the primary cause of cancer treatment failure and death, yet metastatic mechanisms remain incompletely understood. Methods. We studied the molecular basis of head and neck cancer metastasis by transcriptionally profiling 70 samples from 27 patients-matching normal adjacent tissue, primary tumor, and cervical lymph node metastases. Results. We identified tumor-associated expression signatures common to both primary tumors and metastases. Use of matching metastases revealed an additional 46 dysregulated genes associated solely with head and neck cancer metastasis. However, despite being metastasis-specific in our sample set, these 46 genes are concordant with genes previously discovered in primary tumors that metastasized. Conclusions. Although our data and related studies show that most of the metastatic potential appears to be inherent to the primary tumor, they are also consistent with the notion that a limited number of additional clonal changes are necessary to yield the final metastatic cell(s), albeit in a variable temporal order. (C) 2008 Wiley Periodicals.