Microstructural Abnormalities of Striatum and Thalamus in Children with Tourette Syndrome
Microstructural Abnormalities of Striatum and Thalamus in Children with Tourette Syndrome
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DOI：
10.1002/mds.22264
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发表时间：
2008-12-15
影响因子：
8.6
通讯作者：
Chugani, Harry T.
中科院分区：
文献类型：
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作者：
Makki, Malek I.;Behen, Michael;Chugani, Harry T.
我们应用扩散张量MRI（DT-MRI）直接研究皮质下灰质结构内的水扩散率，包括额-纹状体-丘脑（FST）电路，这是有牵连的抽动秽语综合征（TS）的病理生理学。我们调查了23名TS儿童和35名年龄匹配的健康对照（NC）的基底节和丘脑的结构完整性，并检查了DT-MRI测量与抽搐严重程度和共病症状的相关性。我们测量了两个半球的平行（λ（1））和垂直（λ（23））扩散率，平均扩散率（MD）和分数各向异性（FA）。与NC相比，TS组双侧壳核的λ（1）（P = 0.003）和MD（P = 0.027）显著增加，右侧丘脑的λ（23）显著增加（P = 0.008），丘脑FA的不对称性逆转（P = 0.03）。右侧丘脑λ（23）与抽动严重程度呈显著正相关。与NC相比，TS患者的左尾状核体积（P = 0.011）和双侧丘脑体积（左侧，P = 0.035，右侧P = 0.006）显著降低。这些研究结果支持的概念，微结构功能障碍的DT-MRI测量的组件区域的FST电路有助于TS的病理生理。(c)2008运动障碍协会
We applied diffusion-tensor MRI (DT-MRI) to investigate directly the water diffusivity within subcortical gray matter structures comprising the fronto-striato-thalamic (FST) circuit, which is implicated in the pathophysiology of Tourette syndrome (TS). We investigated the structural integrity of basal ganglia and thalamus in 23 children with TS and 35 age-matched healthy controls (NC), and examined the association of DT-MRI measures to tic severity and comorbid symptoms. We measured parallel (lambda(1)) and perpendicular (lambda(23)) diffusivity, mean diffusivity (MD), and fractional anisotropy (FA) in both hemispheres. Compared with NC, the TS group showed a significant increase in lambda(1) (P = 0.003) and MD (P = 0.027) in the bilateral putamen, an increase in lambda(23) in right thalamus (P = 0.008), and a reversed asymmetry of FA (P = 0.03) in the thalamus. There was a significant positive correlation between lambda(23) in right thalamus and tic severity. TS patients showed significantly lower left caudate volume (P = 0.011) and bilateral thalamic volumes (left, P = 0.035, right P = 0.006) compared with NC. These findings support the notion that microstructural dysfunction measured by DT-MRI in component regions of the FST circuit contribute to the pathophysiology in TS. (c) 2008 Movement Disorder Society