12-Lipoxygenase and 12-hydroxyeicosatetraenoic acid regulate hypoxic angiogenesis and survival of pulmonary artery endothelial cells via PI3K/Akt pathway.

12-Lipoxygenase and 12-hydroxyeicosatetraenoic acid regulate hypoxic angiogenesis and survival of pulmonary artery endothelial cells via PI3K/Akt pathway.
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12-脂氧合酶和 12-羟基二十碳四烯酸通过 PI3K/Akt 途径调节缺氧血管生成和肺动脉内皮细胞的存活。

DOI:
10.1152/ajplung.00049.2017
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发表时间:
2018-04
期刊:
Am J Physiol Lung Cell Mol Physiol.
影响因子:
--
通讯作者:
Zhu D.
Zhu D.
中科院分区:
其他
文献类型:
--
作者:
Zhang C;Ma C;Yao H;Zhang L;Yu X;Liu Y;Shen T;Zhang L;Zhang F;Chen X;Zhu D.

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Dysfunction and injury of endothelial cells play critical roles in pulmonary arterial hypertension, including aberrant proliferation, suppressed apoptosis, and excessive angiogenesis. The 12-lipoxygenase and 12-hydroxyeicosatetraenoic acid pathway, which
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