Role of AHR and HIF-1α in Glioblastoma Metabolism.
Role of AHR and HIF-1α in Glioblastoma Metabolism.
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DOI：
10.1016/j.tem.2017.02.009
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发表时间：
2017-06
期刊：
影响因子：
--
通讯作者：
Quintana FJ
中科院分区：
文献类型：
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作者：
Gabriely G;Wheeler MA;Takenaka MC;Quintana FJ
胶质母细胞瘤（GBM）的进展与胶质瘤和免疫细胞的代谢重塑有关，导致有氧糖酵解作为主要的能量来源和生物合成分子。转录因子HIF-1α驱动这种代谢重组。氧水平以及其他因素控制着HIF-1α的活性。此外，配体激活的转录因子AHR调节肿瘤特异性免疫，还可以参与代谢重塑。AHR活性受肿瘤微环境中色氨酸衍生物的调控。因此，肿瘤微环境通过HIF-1α和AHR信号调节胶质瘤和免疫细胞的代谢，调节肿瘤特异性免疫，从而调节肿瘤生长。在这里，我们将回顾HIF-1α和AHR在胶质母细胞瘤中癌症和免疫细胞代谢中的作用。
Glioblastoma (GBM) progression is associated with metabolic remodeling in both glioma and immune cells, resulting in the use of aerobic glycolysis as the main source energy and biosynthetic molecules. The transcription factor HIF-1α drives this metabolic reorganization. Oxygen levels as well as other factors control the activity of HIF-1α. In addition, the ligand-activated transcription factor AHR modulates tumor-specific immunity and can also participate in metabolic remodeling. AHR activity is regulated by tryptophan derivatives present in the tumor microenvironment. Thus, the tumor microenvironment, signaling via HIF-1α and AHR, regulates the metabolism of gliomas and immune cells, modulating tumor-specific immunity and consequently, tumor growth. Here, we will review the roles of HIF-1α and AHR in cancer and immune cell metabolism in glioblastoma.