PPARγ and Its Role in Cardiovascular Diseases.
PPARγ and Its Role in Cardiovascular Diseases.
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DOI：
10.1155/2017/6404638
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发表时间：
2017
期刊：
影响因子：
2.9
通讯作者：
Panchatcharam M
中科院分区：
文献类型：
--
作者：
Chandra M;Miriyala S;Panchatcharam M
过氧化物酶体增殖物激活受体γ（过氧化物酶体增殖物激活受体γ，过氧化物酶体增殖物激活受体γ）是一种配体激活的转录因子，在多种细胞功能以及葡萄糖稳态、脂质代谢和预防氧化应激中发挥作用。PPARγ激活剂已广泛应用于糖尿病的治疗。多年来，人们对PPARγ激活的心脏保护作用进行了广泛研究，使其成为心血管疾病相关疾病的潜在治疗靶点。然而，它们也与不良心血管事件如充血性心力衰竭和心肌梗死相关。本文综述了PPARγ在各种心血管疾病中的作用，并从多项临床试验中总结了目前对PPARγ激动剂的认识。最后，我们还审查了正在开发的新的PPARγ激动剂作为潜在的治疗药物，减少或没有不良反应。
Peroxisome proliferator-activated receptor Gamma (PPARγ), a ligand-activated transcription factor, has a role in various cellular functions as well as glucose homeostasis, lipid metabolism, and prevention of oxidative stress. The activators of PPARγ are already widely used in the treatment of diabetes mellitus. The cardioprotective effect of PPARγ activation has been studied extensively over the years making them potential therapeutic targets in diseases associated with cardiovascular disorders. However, they are also associated with adverse cardiovascular events such as congestive heart failure and myocardial infarction. This review aims to discuss the role of PPARγ in the various cardiovascular diseases and summarize the current knowledge on PPARγ agonists from multiple clinical trials. Finally, we also review the new PPARγ agonists under development as potential therapeutics with reduced or no adverse effects.