Does psychological stress affect the outcome of in vitro fertilization?
Does psychological stress affect the outcome of in vitro fertilization?
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DOI：
10.1093/humrep/dei219
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发表时间：
2005-10-01
影响因子：
6.1
通讯作者：
Möller, A
中科院分区：
文献类型：
--
作者：
Anderheim, L;Holter, H;Möller, A
背景：本研究的目的是在控制已知生理预测因素的情况下，探讨体外受精治疗前和治疗过程中心理应激对体外受精结果的影响。方法：这是一项前瞻性、纵向研究。共有166名妇女在第一次试管婴儿治疗期间接受了研究。他们在两个场合回答了有关心理和社会因素的问卷。采用心理一般幸福感指数（PGWB）衡量心理健康状况，采用14个项目评估不孕不育的心理影响。结果：在心理变量分析中，孕妇与非孕妇之间无差异。妊娠组优质胚胎总数、移植优质胚胎数、移植胚胎数均显著高于非妊娠组。在多变量分析中，移植的优质胚胎数量是唯一与妊娠独立相关的变量。结论：我们没有发现心理应激对IVF治疗结果有任何影响的证据。在为不孕夫妇提供咨询时，通过告知他们这些发现，可能会减少他们在治疗过程中所经历的压力。
BACKGROUND: The aim of the study was to investigate the effect of psychological stress before and during IVF treatment on the outcome of IVF, controlling for known physiological predictors.METHODS: This is a prospective, longitudinal study. A total of 166 women were studied during their first IVF treatment. They answered questionnaires concerning psychological and social factors on two occasions. Psychological well-being was measured by the Psychological General Well-Being (PGWB) index and psychological effects of infertility were assessed by 14 items.RESULTS: In the analysis of the psychological variables, no differences were found between pregnant and nonpregnant women. The total number of good quality embryos, the number of good quality embryos transferred, and the number of embryos transferred were significantly higher in the pregnant than in the non-pregnant group. In a multivariate analysis, the number of good quality embryos transferred was the only variable that was independently associated with pregnancy.CONCLUSIONS: We found no evidence that psychological stress had any influence on the outcome of IVF treatment. When counselling infertile couples, it might be possible to reduce the stress they experience during the treatment procedure by informing them of these findings.