δ-Catenin controls astrocyte morphogenesis via layer-specific astrocyte-neuron cadherin interactions.
δ-Catenin controls astrocyte morphogenesis via layer-specific astrocyte-neuron cadherin interactions.
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DOI：
10.1083/jcb.202303138
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发表时间：
2023-11-06
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Tan et al. show that δ-catenin, previously thought to be neuron specific, is expressed by astrocytes and required both in astrocytes and neurons to control astrocyte morphogenesis. Furthermore, they provide evidence demonstrating how the cadherin–δ-catenin adhesion complex controls astrocyte morphology in a layer-specific manner. Astrocytes control the formation of specific synaptic circuits via cell adhesion and secreted molecules. Astrocyte synaptogenic functions are dependent on the establishment of their complex morphology. However, it is unknown if distinct neuronal cues differentially regulate astrocyte morphogenesis. δ-Catenin was previously thought to be a neuron-specific protein that regulates dendrite morphology. We found δ-catenin is also highly expressed by astrocytes and required both in astrocytes and neurons for astrocyte morphogenesis. δ-Catenin is hypothesized to mediate transcellular interactions through the cadherin family of cell adhesion proteins. We used structural modeling and biochemical analyses to reveal that δ-catenin interacts with the N-cadherin juxtamembrane domain to promote N-cadherin surface expression. An autism-linked δ-catenin point mutation impaired N-cadherin cell surface expression and reduced astrocyte complexity. In the developing mouse cortex, only lower-layer cortical neurons express N-cadherin. Remarkably, when we silenced astrocytic N-cadherin throughout the cortex, only lower-layer astrocyte morphology was disrupted. These findings show that δ-catenin controls astrocyte–neuron cadherin interactions that regulate layer-specific astrocyte morphogenesis.
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影响因子：
9.2
作者：
Israely, I;Costa, RM;Liu, X
通讯作者：
Liu, X
DOI：
10.1016/j.xhgg.2020.100007
发表时间：
2020-10-22
期刊：
HUMAN GENETICS AND GENOMICS ADVANCES
影响因子：
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作者：
Adegbola, Abidemi;Lutz, Richard;Wynshaw-Boris, Anthony
通讯作者：
Wynshaw-Boris, Anthony
影响因子：
5.3
作者：
Arikkath, Jyothi;Israely, Inbal;Reichardt, Louis F.
通讯作者：
Reichardt, Louis F.
影响因子：
3.5
作者：
Belcaro, Chiara;Dipresa, Savina;Fabretto, Antonella
通讯作者：
Fabretto, Antonella
影响因子：
5.3
作者：
通讯作者：
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