CH$_{4}$/CO$_{2}$ Dual Gas Mid-Infrared Anti-Resonance Fiber Optic Sensor for Head and Neck Cancer Detection
CH$_{4}$/CO$_{2}$ Dual Gas Mid-Infrared Anti-Resonance Fiber Optic Sensor for Head and Neck Cancer Detection
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DOI：
10.1109/jlt.2021.3109598
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发表时间：
2021-09
影响因子：
4.7
通讯作者：
Lei Zhu;Shuo Liu
中科院分区：
文献类型：
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作者：
Lei Zhu;Shuo Liu
首次设计了一种四环套式反谐振无节点光纤气体传感器，利用光热法在中红外波段对CO2和CH 4气体进行双传感。采用工作波长分别为2.683 μ m和3.316 μ m的激光器作为CO2和CH 4光谱测量光源。该传感器对CO 2和CH 4的灵敏度分别为3.59 × 10 - 13 W/m 2和5.338 × 10 - 17 W/m 2。当传感器尺寸变化0.3%时，最大误差率为0.318%，具有较好的容错性。通过模拟人体呼出气体中两种气体的含量，得出与头颈癌相关的挥发性有机物的比例关系，完成检查者是否患有头颈癌的初步诊断。它实现了人体头颈部癌症风险的无创实时测量，在临床医学中具有很高的应用价值。
A four-ring nested anti-resonant nodeless fiber gas sensor is first designed, which is used for dual gas sensing of CO$_{2}$ and CH$_{4}$ in the mid-infrared band by photothermal method. Two lasers with operating wavelengths of 2.683 $\mu$m and 3.316 $\mu$m were used as the CO$_{2}$ and CH$_{4}$ spectrum measurement light sources. When the sensor senses CO$_{2}$ and CH$_{4}$, its sensitivity can reach 3.59 $\times\, 10^{-13}$ W/m$^{2}$ and 5.338$\,\times\, 10^{-17}$ W/m$^{2}$, respectively. And the maximum error ratio when the sensor size changes $\pm$0.3 % is 0.318 %, which has good fault tolerance. By simulating the content of the two gases in the exhaled air of the human body, the proportional relationship of the volatile organic compounds related to head and neck cancer is obtained, and the preliminary diagnosis of whether the examiner has head and neck cancer is completed. It realizes the non-invasive real-time measurement of human head and neck cancer risk, which has high application value in clinical medicine.