High percentage of seronegative HCV infections in hemodialysis patients: the need for PCR.
High percentage of seronegative HCV infections in hemodialysis patients: the need for PCR.
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血液透析患者血清阴性 HCV 感染比例较高：需要进行 PCR。
DOI：
10.1159/000150558
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发表时间：
1997
期刊：
影响因子：
4.6
通讯作者：
R. Laufs
中科院分区：
文献类型：
--
作者：
M. Schröter;H. Feucht;P. Schäfer;B. Zöllner;R. Laufs
在接受维持性血液透析的患者中，可以观察到丙型肝炎病毒（HCV）感染的高患病率。在一项前瞻性研究中，273例患者的血清进行了检查，通过血清学试验和PCR的HCV感染的存在。HCV抗体阳性35例（12.8%），其中31例用PCR法可检出HCVRNA。在238例血清学阴性的患者中，12例（5.0%）仅用PCR方法检测到HCV感染。在18个月随访期内，仅在1例患者中观察到血清转化。这些结果表明，在血液透析患者中，PCR是诊断HCV感染所必需的。
Among patients undergoing maintenance hemodialysis, a high prevalence of hepatitis C virus (HCV) infection can be observed. In a prospective study, sera of 273 patients were examined for the presence of HCV infection by serological tests and by PCR. Thirty-five patients (12.8%) were HCV antibody positive, and in 31 of them HCV RNA could be detected by PCR. Among the 238 seronegative patients HCV infection was detected in 12 cases (5.0%) exclusively by PCR. Only in 1 of these patients seroconversion could be observed within the 18-month follow-up period. These findings demonstrate that in hemodialysis patients PCR is necessary for the diagnosis of HCV infection.