Origin of Basophils and Mast Cells
Origin of Basophils and Mast Cells
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DOI：
10.2332/allergolint.08-rai-0067
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发表时间：
2009-03-01
影响因子：
6.8
通讯作者：
Akashi, Koichi
中科院分区：
文献类型：
--
作者：
Arinobu, Yojiro;Iwasaki, Hiromi;Akashi, Koichi
嗜碱性粒细胞和肥大细胞是过敏性疾病进展的主要参与者。虽然这两种细胞类型都起源于造血干细胞，但它们的谱系定型途径和机制一直是血液学中未解决的问题。最近的进展，在ERFACS系统，使前瞻性的祖细胞群体的分离，其读数仅限于嗜碱性粒细胞和/或肥大细胞谱系。这些新分离的祖细胞亚群有助于了解嗜碱性粒细胞和肥大细胞谱系的发育机制，从而可能开发出一种新的治疗过敏性和自身免疫性疾病的策略。在这篇综述中，我们总结了最近的进展，我们的理解嗜碱性粒细胞/肥大细胞的个体发生的细胞基础上。
Basophils and mast cells are major players in the progression of allergic disorders. Although both cell types originate from hematopoietic stem cells, their lineage commitment pathways and mechanisms have been unsolved issues in hematology. Recent advances in the multicolor FACS system enable the prospective isolation of progenitor populations whose readouts are restricted to basophil and/or mast cell lineages. These newly-isolated progenitor subsets are helpful to understand the developmental machinery of basophil and mast cell lineages, leading to the possible exploitation of a novel therapeutic strategy for allergic and autoimmune disorders. In this review, we summarize the recent progress in our understanding of the basophil/mast cell ontogeny on a cellular basis.