Comparative analysis of low-field magnetic resonance imaging in patients with rheumatoid arthritis treated with certolizumab pegol or infliximab
Comparative analysis of low-field magnetic resonance imaging in patients with rheumatoid arthritis treated with certolizumab pegol or infliximab
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DOI：
10.1093/mr/roac138
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发表时间：
2022-11-28
影响因子：
2.2
通讯作者：
Matsumoto，Isao
中科院分区：
文献类型：
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作者：
Hagiwara，Shinya;Tsuboi，Hiroto;Matsumoto，Isao
目的 目的是阐明接受聚乙二醇赛妥珠单抗 (CZP) 和英夫利昔单抗 (IFX) 治疗的类风湿性关节炎 (RA) 患者之间磁共振成像 (MRI) 结果的差异。方法该研究包括接受 CZP 或 IFX 治疗的 RA 患者，并在治疗开始时和治疗 6 个月内再次进行低场 MRI（compacTscan；紧凑型磁共振成像）检查 启动。对 CZP 和 IFX 治疗组之间的背景、临床病程以及开始使用肿瘤坏死因子抑制剂后 MRI 结果的差异进行了比较。通过糜烂、骨髓水肿（BME）和滑膜炎评分来评估MRI表现。结果比较CZP组10例和IFX组18例。 IFX 组的生物疾病缓解抗风湿药物初治率显着高于 CZP 组。 6 个月后，两组的疾病活动度均较基线显着下降。 6 个月后，两组的侵蚀评分均无显着变化。 6个月后，CZP组的BME评分显着下降，而IFX组则没有显着变化。 6 个月后，两组滑膜炎评分均显着下降。结论我们的研究结果表明，对于 RA 患者，CZP 可能比 IFX 更有效地改善 BME。
ObjectivesThe aim is to clarify the differences in magnetic resonance imaging (MRI) findings between rheumatoid arthritis (RA) patients treated with certolizumab pegol (CZP) and infliximab (IFX).MethodsThe study included RA patients who received CZP or IFX and were examined with low-field MRI (compacTscan; compact magnetic resonance imaging) at the beginning and again within 6 months of treatment initiation. Comparisons were made regarding background, clinical course, and differences in MRI findings following initiation of tumour necrosis factor inhibitors between the CZP and IFX treatment groups. MRI findings were evaluated by scoring erosion, bone marrow oedema (BME), and synovitis.ResultsTen cases in CZP and 18 cases in IFX group were compared. The biologic disease-modifying antirheumatic drug–naïve rate in the IFX group was significantly higher than that in the CZP group. After 6 months, disease activities were significantly decreased from baseline in both groups. Erosion score did not change significantly in both groups after 6 months. BME score was significantly decreased in the CZP group after 6 months, whereas in the IFX group, there was no significant change. Synovitis score was significantly decreased in both groups after 6 months.ConclusionsThe findings of our study suggest that, in patients with RA, CZP might improve BME more effectively than IFX.