Sex-Specific Neurotoxic Effects of Organophosphate Pesticides Across the Life Course.
Sex-Specific Neurotoxic Effects of Organophosphate Pesticides Across the Life Course.
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DOI：
10.1007/s40572-017-0171-y
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发表时间：
2017-12
影响因子：
7.9
通讯作者：
Re DB
中科院分区：
文献类型：
--
作者：
Comfort N;Re DB
这篇综述讨论了在整个生命过程中暴露于各种有机磷(OP)杀虫剂的特定性别的影响，以及不同性别观察到的不同脆弱性的潜在原因。性是毒物反应中的一个关键因素，但OP暴露的性别特异性影响，特别是在青少年和成年人中，仍未解决。这在很大程度上是由于研究设计以及暴露和结果评估方面的不一致。暴露于有机磷农药会导致多种不良后果，其影响因素很多，包括性别。已报道的性别效应表明，男性更容易患上OP，这反映了各种神经发育和神经退行性疾病的性别相关性流行，如自闭症和肌萎缩侧索硬化症(ALS)，在这些疾病中，男性风险更大。因此，这篇综述提出，OP暴露引起的生物性别特异性效应可能是神经疾病中观察到的二相性易感性的部分基础。了解不同性别OP暴露的即刻和长期影响，对于促进我们对OP诱导的神经毒性和疾病的理解至关重要。
This review discusses the sex-specific effects of exposure to various organophosphate (OP) pesticides throughout the life course and potential reasons for the differential vulnerabilities observed across sexes. Sex is a crucial factor in the response to toxicants yet the sex-specific effects of OP exposure, particularly in juveniles and adults, remain unresolved. This is largely due to study design and inconsistencies in exposure and outcome assessments. Exposure to OPs results in multiple adverse outcomes influenced by many factors including sex. Reported sex-specific effects suggest that males are more susceptible to OPs, which reflects the sex-dependent prevalence of various neurodevelopmental and neurodegenerative disorders such as autism and amyotrophic lateral sclerosis (ALS), in which males are at greater risk. Thus, this review proposes that the biological sex-specific effects elicited by OP exposure may in part underlie the dimorphic susceptibilities observed in neurological disorders. Understanding the immediate and long-term effects of OP exposure across sexes will be critical in advancing our understanding of OP-induced neurotoxicity and disease.