Synapse biology in the 'circuit-age'-paths toward molecular connectomics.
Synapse biology in the 'circuit-age'-paths toward molecular connectomics.
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DOI：
10.1016/j.conb.2016.12.004
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发表时间：
2017-02
影响因子：
5.7
通讯作者：
de Wit J
中科院分区：
文献类型：
--
作者：
Schreiner D;Savas JN;Herzog E;Brose N;de Wit J
神经连接体是大脑功能的关键决定因素。神经元的精确线路，以及连接它们的突触的传输特征，被认为决定了大脑中的信息处理。虽然最近的技术进步，现在允许定义的解剖和功能的神经连接体在前所未有的分辨率，阐明的分子机制，建立精确的模式的连接和突触的功能特性仍然具有挑战性。在这里，我们描述了控制突触连接和功能的机制分析的遗传方法的力量和局限性，并讨论了如何在蛋白质组学的最新方法的发展可能被用来阐明的分子突触连接体是在神经连接体的基础。
The neural connectome is a critical determinant of brain function. Circuits of precisely wired neurons, and the features of transmission at the synapses connecting them, are thought to dictate information processing in the brain. While recent technological advances now allow to define the anatomical and functional neural connectome at unprecedented resolution, the elucidation of the molecular mechanisms that establish the precise patterns of connectivity and the functional characteristics of synapses has remained challenging. Here, we describe the power and limitations of genetic approaches in the analysis of mechanisms that control synaptic connectivity and function, and discuss how recent methodological developments in proteomics might be used to elucidate the molecular synaptic connectome that is at the basis of the neural connectome.