Toxicity and tolerability of fluoroquinolone-based preventive therapy for childhood contacts of multidrug-resistant tuberculosis.
Toxicity and tolerability of fluoroquinolone-based preventive therapy for childhood contacts of multidrug-resistant tuberculosis.
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以氟喹诺酮为基础的预防性治疗对耐多药结核病儿童接触者的毒性和耐受性。
DOI：
10.1097/inf.0000000000000369
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Hesseling,AnnekeC
中科院分区：
文献类型：
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作者：
Seddon,JamesA;Garcia-Prats,AnthonyJ;Kampmann,Beate;Schaaf,HSimon;Hesseling,AnnekeC
由于药物的溶解度差。虽然间歇性输注会导致更高的峰值水平，但人们认为存在一个“溶解度阈值”，超过该阈值后，血浆两性霉素B浓度的增加不会导致未结合（即活性）药物的增加，而是导致蛋白质结合的增加。因此，尽管间歇输注可能产生更高的两性霉素B峰值水平，但未结合活性药物的浓度可能与间歇输注和连续输注相似。7我们同意Bes等人的观点，即脱氧胆酸两性霉素B可用于大多数儿科患者。应考虑使用持续输注脱氧胆酸两性霉素B，以尽量减少药物相关毒性。需要研究比较持续输注脱氧胆酸两性霉素B和两性霉素B脂质制剂。
by the poor solubility of the drug. Although intermittent infusion results in a higher peak level, there is thought to be a “solubility threshold” above which an increase in plasma amphotericin B concentration does not lead to an increase in unbound, and therefore active, drug, but rather an increase in protein binding. Consequently, although intermittent infusion may produce higher peak levels of amphotericin B, the concentration of unbound active drug may be similar with intermittent and continuous infusion. 7 We agree with Bes et al1 that deoxycholate amphotericin B can be used in most pediatric patients. Consideration should be given to the use of continuous infusion of deoxycholate amphotericin B to minimize drug-related toxicity. Studies comparing continuous infusion of deoxycholate amphotericin B with lipid formulations of amphotericin B are needed.