Suppression of heat-induced p53 accumulation and activation by CDDP or x-rays in human glioblastoma cells.
Suppression of heat-induced p53 accumulation and activation by CDDP or x-rays in human glioblastoma cells.
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CDDP 或 X 射线在人胶质母细胞瘤细胞中抑制热诱导的 p53 积累和激活。
DOI：
10.3892/ijo.13.4.741
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发表时间：
1998
影响因子：
5.2
通讯作者：
E. Kano
中科院分区：
文献类型：
--
作者：
H. Matsumoto;S. Hayashi;H. Shioura;T. Ohtsubo;T. Nishida;R. Kitai;T. Ohnishi;E. Kano
我们发现CDDP或x射线在A-172细胞中显著抑制热诱导的p53积累和激活，而在T98G细胞中则没有。此外，在A-172细胞中观察到CDDP或x射线细胞毒性的相互作用热增强，而在T98G细胞中没有。我们的研究结果表明，CDDP或x射线对热诱导的p53积累和激活的抑制积极地促进了CDDP或x射线细胞毒性的互动高温增强。
We showed that the prominent suppressions of heat-induced accumulation and activation of p53 by CDDP or X-rays were observed in A-172 cells, but not in T98G cells. In addition, the interactive hyperthermic enhancement of CDDP or X-ray cytotoxicity was observed in A-172 cells, but not in T98G cells. Our findings indicate that suppressions of heat-induced accumulation and activation of p53 by CDDP or X-rays contribute positively to an interactive hyperthermic enhancement of CDDP- or X-ray cytotoxicity.