Cell Assembly Signatures Defined by Short-Term Synaptic Plasticity in Cortical Networks
Cell Assembly Signatures Defined by Short-Term Synaptic Plasticity in Cortical Networks
复制标题
DOI：
10.1142/s0129065715500264
复制
发表时间：
2015-11-01
影响因子：
8
通讯作者：
Arbuthnott, Gordon W.
中科院分区：
文献类型：
--
作者：
Carrillo-Reid, Luis;Lopez-Huerta, Violeta G.;Arbuthnott, Gordon W.
细胞组装（CA）假说已被用作解释神经元群如何形成记忆的概念框架。CA被定义为具有同步、重复和顺序活动模式的神经元池。然而，定义CA签名的神经元相互作用和突触特性一直难以检查，因为组装成员的身份和位置通常是未知的。为了研究定义CA的突触特性，我们使用光学和电生理方法记录小鼠皮层培养物中识别出的神经元的活动。人口分析和图论技术使我们能够找到代表网络状态之间重复转换的序列模式。参与重复序列的神经元的全细胞对记录表明，具有强突触连接（伴随放电）的神经元组表现出同步性，显示短期突触抑制（STD），而交替（顺序放电）被认为是在具有较弱突触连接的神经元组中显示短期突触促进（STF）。降低网络的突触权重促进了序列活动模式的产生，而增加突触权重限制了状态转换。因此，在真实的神经元的简单皮层网络中，CA的基本特征，即赫布最初描述的感知和记忆的基础属性，已经存在。
The cell assembly (CA) hypothesis has been used as a conceptual framework to explain how groups of neurons form memories. CAs are defined as neuronal pools with synchronous, recurrent and sequential activity patterns. However, neuronal interactions and synaptic properties that define CAs signatures have been difficult to examine because identities and locations of assembly members are usually unknown. In order to study synaptic properties that define CAs, we used optical and electrophysiological approaches to record activity of identified neurons in mouse cortical cultures. Population analysis and graph theory techniques allowed us to find sequential patterns that represent repetitive transitions between network states. Whole cell pair recordings of neurons participating in repeated sequences demonstrated that synchrony is exhibited by groups of neurons with strong synaptic connectivity (concomitant firing) showing short-term synaptic depression (STD), whereas alternation (sequential firing) is seen in groups of neurons with weaker synaptic connections showing short-term synaptic facilitation (STF). Decreasing synaptic weights of a network promoted the generation of sequential activity patterns, whereas increasing synaptic weights restricted state transitions. Thus in simple cortical networks of real neurons, basic signatures of CAs, the properties that underlie perception and memory in Hebb's original description, are already present.