Blocking in rabbit eyeblink conditioning is not due to learned inattention: Indirect support for an error correction mechanism of blocking
Blocking in rabbit eyeblink conditioning is not due to learned inattention: Indirect support for an error correction mechanism of blocking
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DOI：
10.1007/bf02734248
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发表时间：
2002-10-01
期刊：
影响因子：
--
通讯作者：
Gluck, MA
中科院分区：
文献类型：
--
作者：
Allen, MT;Padilla, Y;Gluck, MA
阻断是一种经典的条件反射任务，其中先前对一个线索（例如音调）的训练减少了对第二个线索（例如灯光）的学习，当随后被训练为音调-灯光复合物时。Rescorla和瓦格纳（1972）的理论认为，阻滞是通过美国调制的纠错机制产生的，而麦克维尔（1973）的理论认为，阻滞是通过习得性注意力不集中机制产生的。在眨眼条件反射的情况下，错误纠正机制被假设发生在小脑，而某种形式的注意力不集中被假设发生在海马区。我们正在检验的假设是，学习性注意力不集中的机制是否参与了兔眨眼条件反射的阻断。如果眨眼条件反射中的阻滞是由习得性注意力不集中的机制产生的，那么对一个先前被阻滞的线索的训练应该比对一个幼稚动物训练该线索要慢。先进行声调训练再进行声调-灯光训练的兔子表现出阻滞。先前被阻断光的兔子获得了与幼稚兔子相同的对光的条件反应。这一发现未能支持这一假设，即阻塞在兔子眨眼条件是由于学习注意力不集中，但支持Rescorla-Wagner的纠错机制。本发现沿着先前关于小脑-脑干回路中的纠错机制的工作（Kim等人，1998）支持这样的理论，即阻塞，至少在兔子眨眼条件反射中，似乎是由于错误纠正机制，而不是学习的注意力不集中机制。
Blocking is a classical conditioning task in which prior training to one cue such as a tone reduces learning about a second cue such as a light, when subsequently trained as a tone-light compound. Blocking has been theorized to come about through a US-modulated error correction mechanism by Rescorla & Wagner (1972) as well as through a mechanism of learned inattention as theorized by Mackintosh (1973). In the case of eyeblink conditioning, an error correction mechanism has been hypothesized to take place in the cerebellum while some form of inattention has been hypothesized to take place in the hippocampal region. The hypothesis we are testing is whether the mechanism of learned inattention is involved in blocking in rabbit eyeblink conditioning. If blocking in eyeblink conditioning is produced by a mechanism of learned inattention, then training to a previously blocked cue should be slower than training to that cue in a naive animal. Rabbits that had received tone training followed by tone-light training exhibited blocking. Rabbits that had been previously blocked to the light acquired conditioned responses to the light at the same rate as naive rabbits. This finding failed to support the hypothesis that blocking in rabbit eyeblink conditioning is due to learned inattention, but does support the Rescorla-Wagner mechanism of error correction. The present finding along with previous work on error correction mechanism in the cerebellar-brainstem circuit (Kim et al., 1998) lend support to the theory that blocking, at least in rabbit eyeblink conditioning, seems to be due to an error correction mechanism rather than a learned inattention mechanism.