RAB and RHO GTPases regulate intestinal crypt cell homeostasis and enterocyte function.
RAB and RHO GTPases regulate intestinal crypt cell homeostasis and enterocyte function.
复制标题
RAB 和 RHO GTPases 调节肠隐窝细胞稳态和肠上皮细胞功能。
DOI：
10.1080/21541248.2016.1159274
复制
发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Gao,Nan
中科院分区：
文献类型：
--
作者：
Zhang,Xiao;Gao,Nan
Recent human and mouse genetic studies have highlighted important contributions of several small GTPases, in particular Rab8a, Cdc42, and Rab11a, to the proper morphogenesis and function of the mature intestinal epithelia. Additional insights about the involvement of these factors in maintaining intestinal stem cell homeostasis have also been obtained. These studies suggest a conserved vesicular and membrane trafficking program utilized by the gastrointestinal tissue to support the rapid epithelial cell turnover and the highly sophisticated physiology of mature epithelial cells.
