Preterm labor: one syndrome, many causes.
Preterm labor: one syndrome, many causes.
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DOI：
10.1126/science.1251816
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发表时间：
2014-08-15
期刊：
影响因子：
--
通讯作者：
Fisher SJ
中科院分区：
文献类型：
--
作者：
Romero R;Dey SK;Fisher SJ
早产与5%-18%的怀孕有关，是婴儿发病率和死亡率的主要原因。自发性早产是一种由多种病理过程引起的综合征，70%的早产是由自发性早产引起的。预防和治疗早产一直是一个长期存在的挑战。我们总结了目前对这种情况所涉及的疾病机制的了解，并回顾了与羊膜内感染、蜕膜衰老和母胎耐受崩溃相关的研究进展。孕激素治疗在高危患者中预防早产的成功是一个乐观的理由。解开危及后代健康的早产之谜，是一项值得投资的艰巨科学挑战。
Preterm birth is associated with 5-18% of pregnancies and is a leading cause of infant morbidity and mortality. Spontaneous preterm labor, a syndrome caused by multiple pathologic processes, leads to 70% of preterm births. The prevention and treatment of preterm labor have been a long-standing challenge. We summarize the current understanding of the mechanisms of disease implicated in this condition, and review advances relevant to intra-amniotic infection, decidual senescence, and breakdown of maternal-fetal tolerance. The success of progestogen treatment to prevent preterm birth in a subset of patients at risk is a cause for optimism. Solving the mystery of preterm labor, which compromises the health of future generations, is a formidable scientific challenge worthy of investment.