Evidence for the transient nature of a neural system supporting goal-directed action.
Evidence for the transient nature of a neural system supporting goal-directed action.
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DOI：
10.1093/cercor/10.8.748
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发表时间：
2000-08
期刊：
影响因子：
3.7
通讯作者：
R. West;Claude Alain
中科院分区：
文献类型：
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作者：
R. West;Claude Alain
支持目标导向行动的神经系统的破坏会导致健康个体的意图失误和前额叶损伤患者的无组织行为。行为研究的证据表明，选择性注意、工作记忆和前瞻性记忆任务的失误本质上是短暂的。在目前的研究中，我们使用事件相关脑电位来证明失误与额叶区域的慢波有关，该慢波在刺激开始之前就开始了，持续了几百毫秒。这慢波的幅度调制的任务要求，表明注意过程可以灵活地分配在服务的目标导向的行动。总之，这些实验的结果表明，失误是由于行动选择系统暂时无法实现个人目标造成的。
Disruption of a neural system supporting goal-directed action gives rise to lapses of intention in healthy individuals and disorganized behavior in patients with prefrontal lesions. Evidence from behavioral studies indicates that the occurrence of lapses in selective attention, working memory and prospective memory tasks is transient in nature. In the current study, we used event-related brain potentials to demonstrate that lapses are associated with a slow wave over the frontal region that begins well before stimulus onset and lasts for several hundred milliseconds. The magnitude of this slow wave was modulated by task demands, indicating that attentional processes can be flexibly allocated in the service of goal-directed action. Together the findings of these experiments indicate that lapses result from a transient inability to bring to bear the goals of the individual upon the action selection system.