Regulation of ERAP1 and ERAP2 genes and their disfunction in human cancer
Regulation of ERAP1 and ERAP2 genes and their disfunction in human cancer
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DOI：
10.1016/j.humimm.2019.02.014
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发表时间：
2019-05-01
期刊：
影响因子：
2.7
通讯作者：
Fruci, Doriana
中科院分区：
文献类型：
--
作者：
Compagnone, Mirco;Cifaldi, Loredana;Fruci, Doriana
内质网（ER）氨基肽酶ERAP 1和ERAP 2是两种多功能酶，在需要修整底物的生物学过程中发挥重要作用，包括产生主要组织相容性复合体（MHC）I类结合肽。在缺乏ERAP酶的情况下，细胞在其表面上表现出不同的肽库，其可以促进NK和CD8（+）T细胞介导的免疫应答。与正常对应物相比，ERAP 1和ERAP 2的表达在肿瘤中经常改变，但这如何影响肿瘤生长和抗肿瘤免疫应答的研究很少。本文综述了ERAP酶的转录和转录后调控的最新知识，并讨论了最近的研究对我们理解ERAP 1和ERAP 2在癌症免疫中的作用的贡献。
The endoplasmic reticulum (ER) aminopeptidases ERAP1 and ERAP2 are two multifunctional enzymes playing an important role in the biological processes requiring trimming of substrates, including the generation of major histocompatibility complex (MHC) class I binding peptides. In the absence of ERAP enzymes, the cells exhibit a different pool of peptides on their surface which can promote both NK and CD8(+) T cell-mediated immune responses. The expression of ERAP1 and ERAP2 is frequently altered in tumors, as compared to their normal counterparts, but how this affects tumor growth and anti-tumor immune responses has been little investigated. This review will provide an overview of current knowledge on transcriptional and post-transcriptional regulations of ERAP enzymes, and will discuss the contribution of recent studies to our understanding of ERAP1 and ERAP2 role in cancer immunity.