Palladium-catalyzed sequential arylation and allylic alkylation of highly functionalized ketones: a concise synthesis of mesembrine.
Palladium-catalyzed sequential arylation and allylic alkylation of highly functionalized ketones: a concise synthesis of mesembrine.
复制标题
DOI：
10.1021/ol802608r
复制
发表时间：
2009-02
期刊：
影响因子：
5.2
通讯作者：
Yuanhong Zhao;Yongyun Zhou;Leilei Liang;Xiaodong Yang;Fengxiang Du;Liang Li;Hongbin Zhang
中科院分区：
文献类型：
--
作者：
Yuanhong Zhao;Yongyun Zhou;Leilei Liang;Xiaodong Yang;Fengxiang Du;Liang Li;Hongbin Zhang
开发了一种前所未有的钯催化高功能化环己酮的芳基化和烯丙基烷基化顺序反应方法。这个新方案只需要一步就能得到含有苯基季碳的有用的构建块。在此基础上，仅用5个步骤就实现了间膜的简明全合成，总收率为22%。
An unprecedented palladium-catalyzed sequential procedure toward arylation and allylic alkylation of highly functionalized cyclohexenones was developed. This new protocol leads to useful building blocks containing a benzylic quaternary carbon in only one step. A concise total synthesis of mesembrine based on this procedure was achieved in only five steps with 22% overall yield.