COVID-19 is an emergent disease of aging.
COVID-19 is an emergent disease of aging.
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DOI：
10.1111/acel.13230
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发表时间：
2020-10
期刊：
影响因子：
7.8
通讯作者：
Gladyshev VN
中科院分区：
文献类型：
--
作者：
Santesmasses D;Castro JP;Zenin AA;Shindyapina AV;Gerashchenko MV;Zhang B;Kerepesi C;Yim SH;Fedichev PO;Gladyshev VN
COVID-19是由SARS-CoV-2冠状病毒引起的持续大流行病，是近年来对公共卫生构成的最大挑战之一。已知SARS-CoV-2优先针对老年受试者和既往有疾病的受试者，但这种年龄依赖性的原因尚不清楚。在这里，我们发现，在所有接受测试的国家，COVID-19的病死率都随着年龄的增长呈指数级增长，翻倍时间接近全因人类死亡率。此外，男性和患有多种年龄相关疾病的人的特点是死亡率增加。此外，全因肺炎的死亡率模式相似。我们进一步报告说，ACE 2（SARS-CoV-2受体）的基因表达随着年龄的增长而在肺中增长，但使用呼吸机的受试者除外。总之，我们的研究结果确定COVID-19是一种衰老的紧急疾病，年龄和年龄相关疾病是其主要风险因素。反过来，这表明COVID-19和一般致命的呼吸道疾病，除了抗病毒方法外，还可以通过针对衰老过程的方法来靶向。本研究将COVID-19确定为老龄化的紧急疾病，基于（a）COVID-19死亡率随年龄呈指数增长，（B）COVID-19死亡率接近全因人类死亡率的两倍时间，（c）男性死亡率高于女性，（d）与既存年龄相关疾病密切相关，以及（e）COVID-19是全因肺炎的一个子集，我们发现这是一种衰老的疾病。
COVID‐19 is an ongoing pandemic caused by the SARS‐CoV‐2 coronavirus that poses one of the greatest challenges to public health in recent years. SARS‐CoV‐2 is known to preferentially target older subjects and those with pre‐existing conditions, but the reason for this age dependence is unclear. Here, we found that the case fatality rate for COVID‐19 grows exponentially with age in all countries tested, with the doubling time approaching that of all‐cause human mortality. In addition, men and those with multiple age‐related diseases are characterized by increased mortality. Moreover, similar mortality patterns were found for all‐cause pneumonia. We further report that the gene expression of ACE2, the SARS‐CoV‐2 receptor, grows in the lung with age, except for subjects on a ventilator. Together, our findings establish COVID‐19 as an emergent disease of aging, and age and age‐related diseases as its major risk factors. In turn, this suggests that COVID‐19, and deadly respiratory diseases in general, may be targeted, in addition to antiviral approaches, by approaches that target the aging process. This study establishes COVID‐19 as an emergent disease of aging, based on (a) an exponential growth of the COVID‐19 mortality rate with age, (b) the COVID‐19 mortality rate doubling time approaching that of all‐cause human mortality, (c) higher mortality in men than in women, (d) strong association with pre‐existing age‐related diseases, and (e) COVID‐19 being a subset of all‐cause pneumonia, which we find itself is a disease of aging.
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DOI：
10.1073/pnas.1714478115
发表时间：
2018-02-20
影响因子：
11.1
作者：
Palmer S;Albergante L;Blackburn CC;Newman TJ
通讯作者：
Newman TJ
DOI：
10.1126/science.aan4673
发表时间：
2019-11-01
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Jaiswal S;Ebert BL
通讯作者：
Ebert BL
影响因子：
10
作者：
Ewig, S.;Birkner, N.;Hoeffken, G.
通讯作者：
Hoeffken, G.
SARS-CoV-2受体ACE2基因表达和调控的个体差异
影响因子：
7.8
作者：
Chen, Jiawei;Jiang, Quanlong;Han, Jing-Dong J.
通讯作者：
Han, Jing-Dong J.
DOI：
10.1016/s1473-3099(20)30243-7
发表时间：
2020-06-01
期刊：
The Lancet. Infectious diseases
影响因子：
--
作者：
Verity, Robert;Okell, Lucy C;Ferguson, Neil M
通讯作者：
Ferguson, Neil M