The use of diffusional kurtosis imaging and neurite orientation dispersion and density imaging of the brain in major depressive disorder
The use of diffusional kurtosis imaging and neurite orientation dispersion and density imaging of the brain in major depressive disorder
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DOI：
10.1016/j.jpsychires.2017.12.011
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发表时间：
2018-03-01
影响因子：
4.8
通讯作者：
Kunugi, Hiroshi
中科院分区：
文献类型：
--
作者：
Ota, Miho;Noda, Takamasa;Kunugi, Hiroshi
弥散峰度成像（DKI）和神经突定向弥散和密度成像（NODDI）是表征人脑神经组织的新型弥散磁共振成像（dMRI）技术。在这项研究中，我们使用这些dMRI技术来评估重度抑郁症（MDD）患者的全脑微结构变化。23例重度抑郁症患者和26例健康受试者进行了dMRI检查。我们比较了两组之间的dMRI指标，并检查了指标与重度抑郁症临床症状之间的关系。与对照组相比，MDD患者在双侧顶叶、右侧顶枕和右侧颞上皮层表现出显著的分数各向异性降低。MDD患者右侧颞上皮层和双侧丘脑后区辐射的平均峰度值显著降低。右侧颞上皮层、双侧岛叶、右侧额下皮层、左侧海马旁区、左侧小脑中部脚和右侧小脑的神经突密度指数降低。在取向弥散指数（ODI）方面，我们发现左丘脑和左枕皮质显著降低，双侧上纵束和左丘脑后辐射束显著升高。此外，汉米尔顿抑郁评定量表-21总分与右额回ODI值之间存在显著正相关。这些结果表明，与DTI方法相比，DIU和NODDI方法可以提供更多关于MDD患者显微结构异常的信息。因此，这些技术有望成为神经影像学研究的信息性方法。
Diffusional kurtosis imaging (DKI) and neurite orientation dispersion and density imaging (NODDI) are new diffusional magnetic resonance imaging (dMRI) techniques for the characterization of neural tissues in human brain. In this study, we used these dMRI techniques to evaluate the whole-brain microstructural changes in patients with major depressive disorder (MDD). Twenty-three patients with MDD and 26 healthy subjects underwent dMRI. We compared the dMRI metrics between the 2 groups and examined the relationships between the metrics and the clinical symptoms of MDD. The MDD patients showed significant fractional anisotropy reduction in the bilateral parietal, right parieto-occipital, and right superior temporal corti, compared with the controls. Mean kurtosis values were significantly reduced in MDD patients in the right superior temporal cortex and bilateral posterior thalamic radiation. Neurite density index reductions were found in the right superior temporal cortex, bilateral insulae, right inferior frontal cortex, left parahippocampal region, left middle cerebellar peduncle, and right cerebellum. Regarding the orientation dispersion index (ODI), we detected significant decreases in the left thalamus and left occipital cortex, and significant increases in the bilateral superior longitudinal fasciculi and left posterior thalamic radiation tract. Further, there were significant positive correlations between the total Hamilton Depression Rating scale-21 scores and the ODI values in the right frontal gyri. These results suggest that the DIU and NODDI methods may provide more information about microstructural abnormalities in patients with MDD than the DTI method. It is thus expected that these techniques will be adopted as the informative methods for neuroimaging study.