Associations between oxytocin receptor genotypes and social cognitive performance in individuals with schizophrenia.
Associations between oxytocin receptor genotypes and social cognitive performance in individuals with schizophrenia.
复制标题
DOI：
10.1016/j.schres.2014.09.006
复制
发表时间：
2014-11
影响因子：
4.5
通讯作者：
Green, Michael F.
中科院分区：
文献类型：
--
作者：
Davis, Michael C.;Horan, William P.;Nurmi, Erika L.;Rizzo, Shemra;Li, Wendy;Sugar, Catherine A.;Green, Michael F.
精神分裂症患者通常表现出与社会功能密切相关的社会认知能力的严重缺陷。为了进一步了解与精神分裂症患者社会认知缺陷相关的遗传变异，我们对74名精神分裂症门诊患者进行了基因分型，这些患者完成了社会认知表现测试，评估了心理化、社会感知、情商以及临床症状。我们评估了先前发现的催产素受体（OXTR）的7个单核苷酸多态性（snp），这些多态性与社会情绪过程具有可复制的关联。7个snp中的一个，rs2268493，其“T”等位基因与综合社会认知指数以及心智化和社会感知的特定测试中的较差表现显著相关。这些snp均与临床症状无关。虽然样本量很小，但这些发现为OXTR基因变异与精神分裂症患者的社会认知障碍有关提供了初步支持。
Individuals with schizophrenia often show substantial deficits in social cognitive abilities, which are strongly associated with social functioning. To advance our understanding of the genetic variation that is associated with social cognitive deficits in schizophrenia, we genotyped 74 schizophrenia outpatients who completed social cognitive performance measures assessing mentalizing, social perception, and emotional intelligence, as well as clinical symptoms. We assessed seven single nucleotide polymorphisms (SNPs) of the oxytocin receptor (OXTR) previously found to show replicable associations with socio-emotional processes. For one of the seven SNPs, rs2268493, the ‘T’ allele was significantly associated with poorer performance on a composite social cognition index, as well as specific tests of mentalizing and social perception. None of the SNPs were associated with clinical symptoms. Though the sample size is small, these findings provide initial support for the involvement of genetic variants of the OXTR in social cognitive impairments in schizophrenia.
登录
查看更多内容
来自1,092个人基因组的遗传变异的综合图。
影响因子：
64.8
作者：
通讯作者：
--
影响因子：
4.9
作者：
Campbell, Daniel B.;Datta, Dibyadeep;Jones, Shaine T.;Lee, Evon Batey;Sutcliffe, James S.;Hammock, Elizabeth A. D.;Levitt, Pat
通讯作者：
Levitt, Pat
影响因子：
3.8
作者：
Macdonald K;Feifel D
通讯作者：
Feifel D
影响因子：
2.5
作者：
Jacob, Suma;Brune, Camille W.;Cook, Edwin H., Jr.
通讯作者：
Cook, Edwin H., Jr.
影响因子：
3.5
作者：
Liu, Xiaoxi;Kawamura, Yoshiya;Sasaki, Tsukasa
通讯作者：
Sasaki, Tsukasa