Influence of low dose oestrogen on circulating prolactin. LH and FSH levels in post-menopausal women.
Influence of low dose oestrogen on circulating prolactin. LH and FSH levels in post-menopausal women.
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低剂量雌激素对循环催乳素的影响。
DOI：
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发表时间：
1976
期刊：
影响因子：
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通讯作者：
M. Vekemans
中科院分区：
文献类型：
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作者：
C. Robyn;M. Vekemans
在5名年龄在52-78岁的绝经后妇女中研究了连续27天每天口服25 μ g炔雌醇对血清催乳素、LH和FSH水平的影响。在给药前、给药期间和给药后采集血样。血清激素测定采用放射免疫法。LH和FSH均从治疗前的120和115 mIU/ml显著下降至雌激素给药3周后的52和51 mIU/ml。治疗中断后2周，LH（90 mIU/ml）和FSH（112 mIU/ml）显著高于治疗最后一周。平均催乳素水平从治疗前的127 μ U/ml增加到雌激素给药10天后的237 μ U/ml（P <0.001）。在4至8天后，这种增加是显著的，并且在处理期的剩余时间内，水平保持约为对照值的两倍。治疗中断两周后，血清催乳素下降（136 μ U/ml）至治疗前水平。这些结果提出了一个问题，即绝经后妇女长期服用雌激素期间这种激素水平升高可能对乳腺癌的发展产生影响。
The effect on serum prolactin, LH and FSH levels of 25 mug ethinyloestradiol administered daily per os during 27 consecutive days was investigated in 5 post-menopausal women aged 52-78. Blood samples were collected before, during and after treatment. The hormones were assayed in serum by radioimmunological methods. Both LH and FSH decreased progressively and significantly from 120 and 115 mIU/ml before treatment to 52 and 51 mIU/ml, respectively after three weeks of oestrogen administration. Two weeks after interruption of treatment, LH (90mIU/ml) and FSH (112 mIU/ml) were significantly higher than during the last week of treatment. Mean prolactin level increased from 127 muU/ml before treatment to 237 muU/ml after 10 days of oestrogen administration (P less than 0.001). This increase was significant after 4 to 8 days and the levels remained about twice as high as the control values for the rest of the treatment period. Two weeks after interruption of treatment, serum prolactin had fallen (136 muU/ml) to the pre-treatment levels. Such results raise the question of possible effects of elevated levels of this hormone during long term oestrogen medication in post-menopausal women on the development of breast cancer.