Effects of estrogen deficiency on the growth of tissue into porous titanium implants.
Effects of estrogen deficiency on the growth of tissue into porous titanium implants.
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DOI：
10.2106/00004623-198870040-00010
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发表时间：
1988-04
期刊：
影响因子：
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通讯作者：
R. Martin;H A Paul;W L Bargar;G. Dannucci;N. Sharkey
中科院分区：
文献类型：
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作者：
R. Martin;H A Paul;W L Bargar;G. Dannucci;N. Sharkey
在切除卵巢的比格犬中研究了全身雌激素缺乏对多孔钛纤维植入物组织生长的影响。5只狗切除了卵巢，5只狗做了假手术。等待四个月后，让循环雌激素水平下降，在每只狗的两侧肱骨近端植入含有四个钛合金网状表面垫的钛合金植入物。2个月后，摘取假体，进行机械推出试验和定量组织学研究。切除卵巢的狗的植入物的推出强度比对照动物低31%。卵巢切除术对骨长入量没有影响，但导致多孔垫内纤维结缔组织的数量显著增加。这种纤维组织的存在似乎对骨植入物固定有重要影响：在对照犬中，强度与骨长入呈正相关，与纤维组织长入负相关，而在切除卵巢的犬中，强度与纤维组织长入呈正相关，而与骨长入完全无关。
The effect of systemic deficiency of estrogen on the growth of tissue into porous titanium-fiber implants was studied in ovariectomized Beagle dogs. Five dogs were ovariectomized and five dogs had a sham operation. After waiting four months to allow the levels of circulating estrogen to decline, a titanium-alloy implant that contained four surface pads of titanium-alloy mesh was implanted in the proximal part of the humerus of each dog bilaterally. Two months later, the implants were harvested and subjected to a mechanical push-out test and quantitative histological study. The push-out strength of the implants from the ovariectomized dogs was 31 per cent less than in the control animals. Ovariectomy caused no difference in the amount of ingrowth of bone but resulted in a significant increase in the amount of fibrous connective tissue within the porous pads. The presence of this fibrous tissue appeared to have an important effect on bone-implant fixation: in the control dogs, strength correlated positively with ingrowth of bone and negatively with ingrowth of fibrous tissue, whereas in the ovariectomized dogs, strength correlated positively with ingrowth of fibrous tissue and not at all with ingrowth of bone.