Adenosine: A neuron-glial transmitter promoting myelination in the CNS in response to action potentials
Adenosine: A neuron-glial transmitter promoting myelination in the CNS in response to action potentials
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DOI：
10.1016/s0896-6273(02)01067-x
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发表时间：
2002-12-05
期刊：
影响因子：
16.2
通讯作者：
Fields, RD
中科院分区：
文献类型：
--
作者：
Stevens, B;Porta, S;Fields, RD
神经元活动影响脑的髓鞘形成，但所涉及的分子机制在很大程度上是未知的。在这里，我们报告，少突胶质细胞祖细胞（OPC）表达功能性腺苷受体，这是激活响应动作电位放电。腺苷作为一种有效的神经递质，抑制OPC增殖，刺激分化，促进髓鞘形成。这种神经胶质细胞信号提供了一种分子机制，促进少突胶质细胞的发育和髓鞘形成的冲动活动，并可能有助于解决争议的冲动活动对髓鞘形成的中枢和外周神经系统的相反影响。
Neuronal activity influences myelination of the brain, but the molecular mechanisms involved are largely unknown. Here, we report that oligodendrocyte progenitor cells (OPCs) express functional adenosine receptors, which are activated in response to action potential firing. Adenosine acts as a potent neuronglial transmitter to inhibit OPC proliferation, stimulate differentiation, and promote the formation of myelin. This neuron-glial signal provides a molecular mechanism for promoting oligodendrocyte development and myelination in response to impulse activity and may help resolve controversy on the opposite effects of impulse activity on myelination in the central and peripheral nervous systems.