Effects of sugar-sweetened and sugar-free cocoa on endothelial function in overweight adults
Effects of sugar-sweetened and sugar-free cocoa on endothelial function in overweight adults
复制标题
DOI：
10.1016/j.ijcard.2009.12.010
复制
发表时间：
2011-05-19
影响因子：
3.5
通讯作者：
Katz, David L.
中科院分区：
文献类型：
--
作者：
Njike, Valentine Yanchou;Faridi, Zubaida;Katz, David L.
背景：研究表明可可对心血管有益；然而，每天摄入无糖和加糖可可饮料对内皮功能（EF）的影响尚未确定。方法：44名成年人（BMI 25-35 kg/m(2)）参加了一项随机、对照、交叉试验。参与者被随机分配到治疗顺序：无糖可可饮料、加糖可可饮料和加糖可可安慰剂。每天治疗6周，洗脱期4周。结果：与安慰剂相比，可可摄入改善了流动介导扩张（FMD）测量的EF（无糖可可：变化，2.4% [95% CI， 1.5至3.2]对-0.8% [95% CI, -1.9至0.3]；差异，3.2% [95% CI， 1.8至4.6];p < 0.001；加糖可可：变化，1.5% [95% CI， 0.6至2.4]对-0.8% [95% CI, -1.9至0.3]；差异，2.3% [95% CI， 0.9至3.7];p=0.002）。食用无糖可可与加糖可可相比，口蹄疫的改善幅度更大，但并不显著。其他心脏风险的生物标志物与基线相比没有明显变化。在整个研究过程中，BMI保持稳定。结论：每日摄入可可可独立于其他心脏风险生物标志物改善EF，且不会导致体重增加。无糖制剂可进一步增强内皮功能。2009爱思唯尔爱尔兰有限公司版权所有。
Background: Studies of cocoa suggest an array of cardiovascular benefits; however, the effects of daily intake of sugar-free and sugar-sweetened cocoa beverages on endothelial function (EF) have yet to be established.Methods: 44 adults (BMI 25-35 kg/m(2)) participated in a randomized, controlled, crossover trial. Participants were randomly assigned to a treatment sequence: sugar-free cocoa beverage, sugar-sweetened cocoa beverage, and sugar-sweetened cocoa-free placebo. Treatments were administered daily for 6 weeks, with a 4-week washout period.Results: Cocoa ingestion improved EF measured as flow-mediated dilation (FMD) compared to placebo (sugar-free cocoa: change, 2.4% [95% CI, 1.5 to 3.2] vs. -0.8% [95% CI, -1.9 to 0.3]; difference, 3.2% [95% CI, 1.8 to 4.6]; p < 0.001 and sugar-sweetened cocoa: change, 1.5% [95% CI, 0.6 to 2.4] vs. -0.8% [95% CI, -1.9 to 0.3]; difference, 2.3% [95% CI, 0.9 to 3.7]; p=0.002). The magnitude of improvement in FMD after consumption of sugar-free versus sugar-sweetened cocoa was greater, but not significantly. Other biomarkers of cardiac risk did not change appreciably from baseline. BMI remained stable throughout the study.Conclusions: Daily cocoa ingestion improves EF independently of other biomarkers of cardiac risk, and does not cause weight gain. Sugar-free preparations may further augment endothelial function. (c) 2009 Elsevier Ireland Ltd. All rights reserved.