Transverse periosteal sectioning and femur growth in the rat
Transverse periosteal sectioning and femur growth in the rat
复制标题
大鼠骨膜横向切片和股骨生长
DOI：
10.1002/ar.1092070213
复制
发表时间：
1983
期刊：
影响因子：
--
通讯作者：
P. Vig
中科院分区：
文献类型：
--
作者：
J. B. McLain;P. Vig
已证实通过长骨的骨膜覆盖的周向切割可暂时增加骨骺生长。这种效应似乎与手术伴随的血管变化无关，并被假设与释放骨膜包膜中的张力有关。本研究旨在通过控制外科手术的影响，并通过使用回归分析分析实验、假手术和对照Sprague道利雄性大鼠同窝仔中股骨长度和比例的动物内和动物间差异，解决先前研究的问题。实验动物右侧股骨行骨膜环切，左侧不手术。假手术组右侧股骨行假手术，不切取骨膜。使用两个多元回归模型分析右到左的差异;一个涉及三个绝对长度测量值作为因变量，而另一个使用这些长度测量值的三个比率作为因变量。比率测量用于反映骨比例的变化。
Circumferential cuts through the periosteal covering of long bones have been demonstrated to transiently increase epiphyseal growth. This effect appears to be independent of vascular changes accompanying surgery and has been hypothesized to relate to releasing tension in the periosteal envelope. This study was designed to address problems of previous investigations by controlling for the effects of the surgical procedure and by using regression analyses to analyze intra‐ and interanimal variations in the length and proportionality of the femur in experimental, sham, and control Sprague‐Dawley male rat littermates. Experimental animals received circumferential periosteal sectioning of the right femur and no operation to the left limb. A sham operation without periosteal sectioning was performed on the right femur in the sham group. Right to left differences were analyzed using two multiple regression models; one involved three absolute length measurements as the dependent variables, while the other used the three ratios of these length measurements as the dependent variables. The ratio measures were utilized to reflect changes in bone proportionality.