Epidemiology of nosocomial infections in selected neonatal intensive care units in Colombia, South America.
Epidemiology of nosocomial infections in selected neonatal intensive care units in Colombia, South America.
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DOI：
10.1038/sj.jp.7211345
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发表时间：
2005-08-01
期刊：
影响因子：
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通讯作者：
Leon, Angela
中科院分区：
文献类型：
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作者：
Efird, Meica M;Rojas, Mario A;Leon, Angela
目的：发展中国家新生儿重症监护病房院内感染（NI）的流行病学研究很少。我们在南非哥伦比亚选定的新生儿单位进行了一项前瞻性研究，以描述发病率、致病微生物和机构间差异。研究设计：前瞻性地收集2001年2月20日至8月30日8个新生儿病房的数据。NI定义为住院72小时后诊断出经培养证实的感染，并使用抗生素治疗50 ~ 30天。线性回归模型用于描述制度变量与NI率之间的关系。结果：共有1504名婴儿住院时间超过72小时，因此存在NI风险。其中，80例患者中报告127例感染（5.3%）。发病率密度为6.2 / 1000患者日。血液感染占NIs的78%。革兰氏阴性菌多于革兰氏阳性菌（55% vs 38%），在<或=2000 g的婴儿中普遍存在（54%）。最常见的病原体是表皮葡萄球菌（26%）和肺炎克雷伯菌（12%）。结论：革兰氏阴性菌在哥伦比亚的婴儿中占主导地位
OBJECTIVE: The epidemiology of nosocomial infections (NI) in neonatal intensive care units in developing countries has been poorly studied. We conducted a prospective study in selected neonatal units in Colombia, SA, to describe the incidence rate, causative organisms, and interinstitutional differences.STUDY DESIGN: Data were collected prospectively from February 20 to August 30, 2001 from eight neonatal units. NI was defined as culture-proven infection diagnosed after 72 h of hospitalization, resulting in treatment with antibiotics for >3 days. Linear regression models were used to describe associations between institutional variables and NI rates.RESULTS: A total of 1504 infants were hospitalized for more than 72 h, and therefore, at risk for NI. Of all, 127 infections were reported among 80 patients (5.3%). The incidence density rate was 6.2 per 1000 patient-days. Bloodstream infections accounted for 78% of NIs. Gram-negative organisms predominated over gram-positive organisms (55 vs 38%) and were prevalent in infants < or =2000 g (54%). The most common pathogens were Staphylococcus epidermidis (26%) and Klebsiella pneumonia (12%).CONCLUSION: Gram-negative organisms predominate in Colombia among infants