Controlled Release of Growth Factors for Regenerative Medicine
Controlled Release of Growth Factors for Regenerative Medicine
复制标题
再生医学中生长因子的受控释放
DOI：
10.2174/1381612821666150115154602
复制
发表时间：
2015-01-01
影响因子：
3.1
通讯作者：
Wang, Xiaohong
中科院分区：
文献类型：
--
作者：
Liu, Libiao;Zhou, Xinwei;Wang, Xiaohong
如何科学释放生长因子促进干细胞的增殖和分化是再生医学领域最重要的研究热点之一。在控释系统中，生长因子、细胞外基质或生物材料载体，有时还有干细胞一起形成一个几何整体。生物材料载体为gf提供了粘附、固定、封装或/和保护的支撑结构。作为一个整体，gf在细胞上的释放速度和节奏通常是非常微妙和精确的。到目前为止，临床应用的最佳策略是将GFs封装在微球中的组合系统，特别是将GFs与生物材料载体结合的纳米或微封装技术。本文综述了再生医学中GF传递系统的研究进展，并从两个方面进行了展望：一是干细胞和GF在再生医学中的应用，包括它们各自的应用条件和功能；另一种是可控的GF释放系统，其中各种GF的释放是有序的，连续的，而不是简单而快速的扩散，包括它们各自的机遇和挑战。
How to release growth factors (GFs) scientifically to promote stem cell proliferation and differentiation is one of the most significant research focuses in the field of regenerative medicine. In a controlled release system, growth factors, extracellular matrices or biomaterial carriers, and sometimes stem cells together form a geometric entirety. Biomaterial carriers provide GFs with a support structure to be adhered, immobilized, encapsulated or/and protected. As a unity, the release rate and rhythm of GFs on cells are normally very delicate and precise. Up to now, the best strategy for clinical applications is the combination systems that encapsulate GFs in microspheres, particularly the nano- or micro-encapsulation techniques integrated GFs with biomaterial carriers. In this mini review, we summarize the current progress in GF delivery systems for regenerative medicine and provide an outlook on two main aspects: one is the classes of stem cells and GFs that have been used frequently in regenerative medicine, including their respective application conditions and functions; the other is the controlled GF release systems, in which various GFs are released orderly and continuously without diffusing simply and rapidly, including their respective opportunities and challenges.