The validation of the patient perception of bladder condition (PPBC): A single-item global measure for patients with overactive bladder
The validation of the patient perception of bladder condition (PPBC): A single-item global measure for patients with overactive bladder
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DOI：
10.1016/j.eururo.2006.01.007
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发表时间：
2006-06-01
期刊：
影响因子：
23.4
通讯作者：
Abrams, Paul
中科院分区：
文献类型：
--
作者：
Coyne, Karin S.;Matza, Louis S.;Abrams, Paul
目的：本研究的目的是评估膀胱过度活动症（OAB）的有效性和反应性的全球措施，患者感知膀胱条件（PPBC）。方法：事后分析进行了两个12周的临床试验OAB（研究1：n = 865;研究2：n = 520）。除PPBC外，患者还完成了两项特定条件的健康相关生活质量（HRQL）测量，即膀胱过度活动问卷（OAB-q）和国王健康问卷（KHQ），以及基线和12周的膀胱日记。通过与基线日记、OAB-q和KHQ的相关性评估PPBC的有效性。PPBC的反应性进行了评估，使用相关性和一般线性模型，以评估PPBC的变化和日记，OAB-Q，和KHQ.Results的变化之间的关联程度：两个样本主要是妇女和白色的平均年龄为61.0和58.8岁。大多数患者为失禁（75.3%和80.4%），最大比例的患者表明其在基线时PPBC上有“中度问题”（47.5%和51.2%）。在基线和PPBC与膀胱日记（p < 0.001）、OAB-q（p <0.001）和KHQ（p < 0.01）之间的变化评分之间存在显著相关性。在这两项研究中，主要PPBC改善的患者有显着更大的减少频率，紧迫性发作，失禁发作，和症状困扰和显着更大的改善HRQL比患者只有一个轻微的PPBC improvement.Conclusion：的PPBC，全球患者报告的膀胱状况的措施，表现出良好的结构效度和变化的反应性。这些发现支持使用PPBC作为OAB患者膀胱状况的总体评估。(c)2006 Elsevier B. V.保留所有权利。
Objectives: The purpose of this study was to evaluate the validity and responsiveness of a global measure for overactive bladder (OAB), the Patient Perception of Bladder Condition (PPBC).Methods: Post-hoc analyses were conducted on two 12-wk clinical trials for OAB (Study 1: n = 865; Study 2: n = 520). In addition to the PPBC, patients completed two condition-specific health-related quality of life (HRQL) measures, the Overactive Bladder Questionnaire (OAB-q) and King's Health Questionnaire (KHQ), and bladder diaries at baseline and 12 wk. Validity of the PPBC was evaluated through correlations with baseline diaries, OAB-q, and KHQ. The responsiveness of the PPBC was evaluated using correlations and general linear models to assess the degree of association between change in PPBC and change in the diaries, OAB-q, and KHQ.Results: Both samples were primarily women and white with mean ages of 61.0 and 58.8 yr. The majority of patients were incontinent (75.3% and 80.4%) with the greatest proportion of patients indicating that they had "moderate problems" (47.5% and 51.2%) on the PPBC at baseline. Significant correlations were present at baseline and among change scores between the PPBC and the bladder diaries (p < 0.001), OAB-q (p < 0.001), and KHQ (p < 0.01). in both studies, patients with major PPBC improvement had significantly greater reductions in frequency, urgency episodes, incontinence episodes, and Symptom Bother and significantly greater improvements in HRQL than patients with only a minor PPBC improvement.Conclusion: The PPBC, a global patient-reported measure of bladder condition, demonstrated good construct validity and responsiveness to change. These findings support the use of the PPBC as a global assessment of bladder condition among patients with OAB. (c) 2006 Elsevier B.V. All rights reserved.