Effects of Age, Sex, and Axial Length on the Three-Dimensional Profile of Normal Macular Layer Structures
Effects of Age, Sex, and Axial Length on the Three-Dimensional Profile of Normal Macular Layer Structures
复制标题
DOI：
10.1167/iovs.11-8388
复制
发表时间：
2011-11-01
影响因子：
4.4
通讯作者：
Yoshimura, Nagahisa
中科院分区：
文献类型：
--
作者：
Ooto, Sotaro;Hangai, Masanori;Yoshimura, Nagahisa
目的.采用光谱域光学相干断层扫描（SD-OCT）技术，研究健康人群视网膜各层厚度的性别差异和年龄变化。在日本的七个研究所，使用SD-OCT和一种新的自动分割协议测量了256名健康受试者的视网膜神经纤维层（RNFL）、神经节细胞层（GCL）、内丛状层（IPL）、内核层（INL）、外丛状层（OPL）、外核层（ONL）、光感受器内段（IS）和光感受器外段（OS）的平均厚度。每层测量值的互操作变异系数范围为0.012至0.038。RNFL、GCL、IPL和INL在中心凹区最薄，而OPL + ONL和OS在该区域最厚。男性INL和OPL + ONL的平均厚度显著更大（分别为P = 0.002和0.001）。然而，女性的平均RNFL厚度更大（P = 0.006）。RNFL、GCL、IPL、INL和IS的厚度与年龄呈负相关。OPL + ONL的厚度与年龄无关，OS的厚度与年龄呈正相关。视网膜内层（RNFL + GCL + IPL）厚度与年龄呈负相关（P < 0.001），而视网膜外层（OPL + ONL + IS + OS）厚度与年龄无关。各层厚度与眼轴长度无相关性。在健康眼的SD-OCT图像上测量的黄斑层厚度显示出显著的性别和年龄差异。这些发现应告知视网膜疾病和青光眼的SD-OCT研究中的黄斑层厚度分析。（Invest Ophthalmol维斯科学。2011;52：8769-8779）DOI：10.1167/iovs.11-8388
PURPOSE. To identify sex-related differences and age-related changes in individual retinal layer thicknesses in a population of healthy eyes across the lifespan, using spectral domain optical coherence tomography (SD-OCT).METHODS. In seven institutes in Japan, mean thicknesses of the retinal nerve fiber layer (RNFL), ganglion cell layer (GCL), inner plexiform layer (IPL), inner nuclear layer (INL), outer plexiform layer (OPL), outer nuclear layer (ONL), photoreceptor inner segment (IS), and photoreceptor outer segment (OS) were measured using SD-OCT with a new automated segmentation protocol in 256 healthy subjects.RESULTS. Interoperator coefficients of variability for measurements of each layer ranged from 0.012 to 0.038. The RNFL, GCL, IPL, and INL were thinnest in the foveal area, whereas the OPL + ONL and OS were thickest in this area. Mean thicknesses of the INL and the OPL + ONL were significantly greater in men (P = 0.002 and 0.001, respectively). However, mean RNFL thickness was greater in women (P = 0.006). Thicknesses of the RNFL, GCL, IPL, INL, and IS correlated negatively with age. Thickness of the OPL + ONL was not correlated with age, and thickness of the OS correlated positively with age. Inner retinal (RNFL + GCL + IPL) thickness over the whole macula correlated negatively with age (P < 0.001), but outer retinal (OPL + ONL + IS + OS) thickness did not. Thicknesses of layers did not correlate with axial length.CONCLUSIONS. Macular layer thicknesses measured on SD-OCT images in healthy eyes showed significant variations by sex and age. These findings should inform macular layer thickness analyses in SD-OCT studies of retinal diseases and glaucoma. (Invest Ophthalmol Vis Sci. 2011;52:8769-8779) DOI:10.1167/iovs.11-8388