The surgical treatment of stage I cutaneous melanoma.
The surgical treatment of stage I cutaneous melanoma.
复制标题
I期皮肤黑色素瘤的手术治疗。
DOI：
10.1016/s0305-7372(78)80013-9
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发表时间：
1978
影响因子：
11.8
通讯作者：
A. Breslow
中科院分区：
文献类型：
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作者：
A. Breslow
8.卫星L ~ 9。有丝分裂率10. 11.第11章.肿瘤大小：A。体积B。直径c。最近对肿瘤厚度进行了综述（5），仅对与肿瘤组织学评价有关的发现进行总结，转移率和死亡率与肿瘤最大厚度密切相关（2），对于四肢肿瘤，这些关系几乎是线性的（3）。肿瘤无消退迹象且不超过0。75 mm厚的转移率约为1 ~ 2/0，而有消退迹象的转移率为21.70/0（5，！0）。死亡率和侵袭程度之间的相关性是：由于范围较广，所以不太好。同一平面肿瘤间的厚度差异。通过直接比较（5）和多元分析！s的厚度和水平（1，3），它似乎是一个水平。厚度的因变量，并没有增加我们的评估，一旦厚度测量。对于组织学类型的黑色素瘤似乎也是如此。对于Simila的肿瘤！~结节性和浅表扩散性黑色素瘤的复发率相同。对于雀斑样痣-恶性黑色素瘤也可能如此。这种类型的厚肿瘤的发生率很低，我们不能确定。几项研究（8，15，17; 18，25）表明皮肤黑色素瘤的死亡率与有丝分裂发生率之间存在相关性。
8. SatellitosL~ 9. Mitotic rate 10. L~ cel oflnvesion 11. Size of tumor: a. Volume b. Diameter c. Thickness recently been reviewed (5) and only the findings concerned with the histologic evaluation oft e tumor will besummarmed, the metastatlcand mortalityrates are Closely correlated with maximal tumor thickness~(2) and these relationships are almost linear for tumors of the extremities (3). Tumors without evidence of regression and no more than0. 75 mrn thick have a metastatic rate of about 1 to 2/0 whilethose with evidence of regression have a metastatic rate of 21.70/o (5,! 0). The correlation between mortality and the-level of invasion is: not as good because of the wide. variation in thickness among tumors o£ the same level. By direct comparison (5) and by multivariate analys! s of thickness and level (1, 3), it appears that the level is a. dependent variable of thickness and adds nothing to our evaluation 0fprognosis0nce thickness is measured. This also appears to be true for the histplogic type of melanoma. For tumors of Simila!~ thiekness and treatment, the prognosisis the same for nodular: and for superficial spreading melanomas. This is also probably true for lentigo-m'aligna meIanomas tlioUgh the incidence of thick tumors ofthis type is s0~ low-: that we Cann0t-be~ Certain, Several studies (8, 15i~ i 7; 18, 25) Show a correlation between the mortality rate-and the incidence of imitoses in cutaneous melanoma.