Recreational drug use, polydrug use, and sexual behaviour in HIV-diagnosed men who have sex with men in the UK: results from the cross-sectional ASTRA study
Recreational drug use, polydrug use, and sexual behaviour in HIV-diagnosed men who have sex with men in the UK: results from the cross-sectional ASTRA study
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DOI：
10.1016/s2352-3018(14)70001-3
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发表时间：
2014-10-01
期刊：
影响因子：
16.1
通讯作者：
Lampe, Fiona C.
中科院分区：
文献类型：
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作者：
Daskalopoulou, Marina;Rodger, Alison;Lampe, Fiona C.
男男性行为者（MSM）的频繁吸毒令人担忧，因为它可能与艾滋病毒和其他性传播感染的传播有关。在英国，关于艾滋病毒诊断的男男性行为者使用药物的证据受到研究人群代表性的限制。我们描述的艾滋病毒诊断的男男性接触者在UK.Methods的药物使用和性行为的关联模式，我们使用的数据从横断面ASTRA研究，招募参与者年龄在18岁或以上的艾滋病毒从8个艾滋病毒门诊诊所在英国之间的2011年2月1日，2012年12月31日。我们检查了MSM的数据，评估了过去3个月内娱乐性药物使用和多种药物使用的流行率，以及与社会人口统计学和HIV相关因素的相关性。我们研究了在过去的3个月里，多种药物的使用与无避孕套性行为的措施和其他性行为的关联。结果我们的分析包括2248男男性接触者的数据：2136人（95%）是同性恋，1973人（89%）是白色，1904人（85%）正在接受抗逆转录病毒治疗（ART），1682例（76%）的病毒载量为50拷贝/mL或更低。1138人（51%）在过去3个月内使用过娱乐性药物; 608人（27%）使用亚硝酸盐，477人（21%）使用大麻，460人（21%）使用勃起功能障碍药物，453人（20%）使用可卡因，280人（13%）使用氯胺酮，258人（12%）使用3，4-亚甲二氧基-N-甲基苯丙胺（MDMA），221例（10%）使用γ-羟基丁酸酯或γ-丁内酯，175例（8%）使用甲基苯丙胺，162例（7%）使用甲氧麻黄酮。在1138名吸毒者中，529人（47%）使用三种或三种以上药物，241人（21%）使用五种或五种以上药物。注射吸毒的患病率为3%（n=68）。药物使用与年轻年龄独立相关（p
Background Recreational drug use in men who have sex with men (MSM) is of concern because it might be linked to the transmission of HIV and other sexually transmitted infections. Evidence about drug use in HIV-diagnosed MSM in the UK is limited by representativeness of the study populations. We describe patterns of drug use and associations with sexual behaviours in HIV-diagnosed MSM in the UK.Methods We used data from the cross-sectional ASTRA study, which recruited participants aged 18 years or older with HIV from eight HIV outpatient clinics in the UK between Feb 1, 2011, and Dec 31, 2012. We examined data for MSM, assessing the prevalence of recreational drug use and polydrug use in the previous 3 months and associations with sociodemographic and HIV-related factors. We examined the association of polydrug use with measures of condomless sex in the previous 3 months and with other sexual behaviours.Findings Our analysis included data for 2248 MSM: 2136 (95%) were gay, 1973 (89%) were white, 1904 (85%) were on antiretroviral treatment (ART), and 1682 (76%) had a viral load of 50 copies per mL or lower. 1138 (51%) used recreational drugs in the previous 3 months; 608 (27%) used nitrites, 477 (21%) used cannabis, 460 (21%) used erectile dysfunction drugs, 453 (20%) used cocaine, 280 (13%) used ketamine, 258 (12%) used 3,4-methylenedioxy-N-methylamphetamine (MDMA), 221 (10%) used gamma-hydroxybutyrate or gamma-butyrolactone, 175 (8%) used methamphetamine, and 162 (7%) used mephedrone. In the 1138 individuals who used drugs, 529 (47%) used three or more drugs and 241 (21%) used five or more. Prevalence of injection drug use was 3% (n=68). Drug use was independently associated with younger age (p