Attenuating posttraumatic distress with omega-3 polyunsaturated fatty acids among disaster medical assistance team members after the Great East Japan Earthquake: the APOP randomized controlled trial.
Attenuating posttraumatic distress with omega-3 polyunsaturated fatty acids among disaster medical assistance team members after the Great East Japan Earthquake: the APOP randomized controlled trial.
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DOI：
10.1186/1471-244x-11-132
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发表时间：
2011-08-16
期刊：
影响因子：
4.4
通讯作者：
Koido Y
中科院分区：
文献类型：
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作者：
Matsuoka Y;Nishi D;Nakaya N;Sone T;Hamazaki K;Hamazaki T;Koido Y
2011年3月11日，日本有史以来最强烈的9.0级地震和大规模海啸袭击了三陆地区的海岸。灾难医疗援助队是一个移动的医疗队，在灾难的紧急阶段部署，经过专门培训，被派往遭受大规模破坏和多名伤病人员伤亡的地区。之前的研究报告了救援人员的突发事件应激（即创伤后应激障碍症状和抑郁症状）以及筛查和预防创伤后应激障碍的必要性。到目前为止，我们已经在一项公开试验中表明，严重受伤患者的创伤后应激障碍症状可以通过服用旨在刺激海马神经发生的ω-3脂肪酸来减轻。本研究旨在确定东日本大地震后灾难医疗援助队成员使用omega-3多不饱和脂肪酸减轻创伤后痛苦的有效性，目前正在进行的APOP随机对照试验。首先，我们将提供有关创伤后痛苦的心理教育，这在部署到灾区的灾难医疗援助队成员的反应人员中很常见。第二，将进行观察性研究，以评估医疗活动结束后的危急事件压力。第三，同意参与干预研究的团队成员将被随机分为一组，给予omega-3脂肪酸补充剂，另一组不给予补充剂。结果将在补充剂运送给团队成员后12周进行评估。应对灾难应对者的重大事件应激反应的措施很重要，但没有实质性证据表明这些措施与预防创伤后应激障碍有关。因此，通过这项研究证实，摄入omega-3脂肪酸补充剂作为一种简单的预防措施，对重大事件压力将具有重要意义。UMIN临床试验注册中心，UMIN 000005367
On March 11, 2011, a magnitude 9.0 earthquake, the most powerful ever recorded in Japan, and a massive tsunami struck off the coast of the Sanriku region. A Disaster Medical Assistance Team, a mobile medical team with specialized training that is deployed during the acute phase of a disaster, was dispatched to areas with large-scale destruction and multiple injured and sick casualties. Previous studies have reported critical incident stress (i.e. posttraumatic stress disorder symptoms and depressive symptoms) among rescue workers as well as the need for screening and prevention for posttraumatic stress disorder. So far we have shown in an open trial that posttraumatic stress disorder symptoms in critically injured patients can be reduced by taking omega-3 fatty acids intended to stimulate hippocampal neurogenesis. This study is designed to determine the effectiveness of attenuating posttraumatic distress with omega-3 polyunsaturated fatty acids among Disaster Medical Assistance Team members after the Great East Japan Earthquake, and is named the APOP randomized controlled trial which is currently ongoing. First, we will provide psycho-education on posttraumatic distress, which is common in responders to the Disaster Medical Assistance Team members deployed to the disaster area. Second, observational research will be conducted to evaluate critical incident stress following the completion of medical activities. Third, team members who provide consent to participate in the intervention research will be randomly divided into a group given an omega-3 fatty acid supplement and a group not given the supplements. Outcome will be evaluated at 12 weeks after the supplements are shipped to the team members. Measures that address critical incident stress in disaster responders are important, but there is no substantial evidence that links such measures with prevention of posttraumatic stress disorder. Thus, any confirmation through this study that the intake of omega-3 fatty acid supplements serves as a simple preventative measure for critical incident stress will be of great significance. UMIN Clinical Trials Registry, UMIN000005367