Comorbidity of irritable bowel syndrome, panic disorder, and agoraphobia in a Japanese representative sample
Comorbidity of irritable bowel syndrome, panic disorder, and agoraphobia in a Japanese representative sample
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DOI：
10.1111/j.1572-0241.2004.04048.x
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发表时间：
2004-02-01
影响因子：
9.8
通讯作者：
Kuboki, T
中科院分区：
文献类型：
--
作者：
Kumano, H;Kaiya, H;Kuboki, T
目的：肠易激综合征（IBS）被认为是一种跨文化的功能性肠病，具有较高的合并症和精神疾病，但在日本从未进行过精心设计的流行病学研究。本研究的目的是建立IBS的患病率，连同惊恐障碍（PD）和广场恐怖症的共病率，采用大规模的调查分层随机sampling.METHOD：共4,000名年龄在20-69岁的受试者完成了一份问卷，并对结果进行加权，以确保日本一般人群的代表性。调查问卷涵盖了IBS、PD和广场恐怖症的主要症状。按性别计算IBS及其亚型的患病率。PD和广场恐怖症与IBS的共患病率与非IBS受试者的发病率进行了比较，并在IBS受试者的共患病率谁咨询了医生对他们的症状，并在那些谁没有compared.RESULTS：IBS的患病率为6.1%。女性明显高于男性。腹泻为主的IBS在男性中更普遍，便秘为主的IBS在女性中更普遍。IBS患者PD和广场恐怖症的发生率显著高于非IBS患者。女性和男性IBS受试者之间的并发症没有差异，而发病率显着高于男性非IBS受试者，和并发症之间没有显着差异consulter和nonconsulter subjects.CONCLUSIONS：IBS的患病率和它的并发症与PD和广场恐怖症在日本被证明是类似的西方工业化国家的报道。
OBJECTIVES: Irritable bowel syndrome (IBS) is considered to be a transcultural functional bowel disorder with high comorbidity and psychiatric disorders; but well-designed epidemiologic studies have never been performed in Japan. The purpose of this study was to establish the prevalence of IBS, together with the comorbiclity rates of panic disorder (PD) and agoraphobia, employing a large-scale survey based on stratified random sampling.METHOD: A total of 4,000 subjects aged 20-69 years completed a questionnaire and the results were weighted to ensure representativeness of the Japanese general population. The questionnaire covered key symptoms of IBS, PD, and agoraphobia. The prevalence of IBS and its subtypes was calculated by gender. The comorbidity of PD and agoraphobia with IBS was compared with morbidity in non-IBS subjects; and comorbidity in IBS subjects who had consulted medical practitioners regarding their symptoms and in those who had not was also compared.RESULTS: The prevalence of IBS was 6.1% in total. It was significantly higher in females than in males. Diarrhea-predominant IBS was more prevalent in males and constipation-predominant IBS in females. The morbidity rates of PD and agoraphobia were significantly higher in IBS than in non-IBS subjects. Comorbidity did not differ between female and male IBS subjects, while morbidity was significantly higher in female than in male non-IBS subjects; and comorbidity did not differ between consulter and nonconsulter subjects.CONCLUSIONS: The prevalence of IBS and its comorbidity with PD and agoraphobia in Japan were demonstrated to be similar to those reported in Western industrialized countries.