Polydipsia in rhesus monkeys deficient in omega-3 fatty acids.
Polydipsia in rhesus monkeys deficient in omega-3 fatty acids.
复制标题
缺乏 omega-3 脂肪酸的恒河猴出现烦渴。
DOI：
10.1016/0031-9384(90)90149-x
复制
发表时间：
1990
影响因子：
2.9
通讯作者：
Connor,WE
中科院分区：
文献类型：
--
作者：
Reisbick,S;Neuringer,M;Hasnain,R;Connor,WE
Omega-3 fatty acids are a major component of neural membranes. They are essential nutrients for normal biochemical development of the brain and retina and may affect behavior. In our studies of long-term dietary omega-3 fatty acid deficiency, we have found a new effect of this deficiency in rhesus monkeys. Deficient monkeys visited the home cage drinking spout more frequently than controls (Experiment 1), and drank more water over 24 hours (Experiment 3), ahe increase in intake was mirrored by increased combined output of urine + feces over 24 hours (Experiment 3), and was not due to spillage (Experiment 4). The dietary deficiency greatly reduced omega-3 fatty acids in red blood cells but did not affect serum electrolyte levels. The changes in fluid intake and output may be related to direct or indirect effects on central or peripheral control mechanisms for drinking or excretion, which may be mediated by altered composition of neural or other membranes or changes in eicosanoid metabolism.
