Ligation of metabotropic glutamate receptor 3 (Grm3) ameliorates lupus-like disease by reducing B cells
Ligation of metabotropic glutamate receptor 3 (Grm3) ameliorates lupus-like disease by reducing B cells
复制标题
连接代谢型谷氨酸受体 3 (Grm3) 通过减少 B 细胞来改善狼疮样疾病
DOI：
10.1016/j.clim.2015.05.016
复制
发表时间：
2015-10-01
影响因子：
8.6
通讯作者：
Wang, Renxi
中科院分区：
文献类型：
--
作者：
Ma, Ning;Liu, Xiaoling;Wang, Renxi
Recently B-cell activating factor (BAFF) was identified by our group and others as a novel therapeutic target for the treatment of autoimmune diseases. To expand upon this, we utilized microarrays to screen for molecules upregulated in B cells from BAFF-inhibited mice with lupus-like disease and identified metabotropic glutamate receptor 3 (Grm3). In addition to confirming the expression of this receptor in B cells, a synthetic agonist of Grm3 was found to downregulate B cells and ameliorate autoimmune symptoms in mice. Conversely, a Grm3 antagonist increased B-cell numbers and further aggravated disease. Thus, these results suggest that activation of Grm3 ameliorates lupus-like disease in mice by reducing B cell numbers. Not only do the findings presented in this study increase our understanding of the inhibitory signals initiated on the surface of B cells, but they also identify a novel potential target for the treatment of autoimmune diseases. (C) 2015 Elsevier Inc. All rights reserved.
