Direct cortical control of 3D neuroprosthetic devices
Direct cortical control of 3D neuroprosthetic devices
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DOI：
10.1126/science.1070291
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发表时间：
2002-06-07
期刊：
影响因子：
56.9
通讯作者：
Schwartz, AB
中科院分区：
文献类型：
--
作者：
Taylor, DM;Tillery, SIH;Schwartz, AB
当使用适当的算法实时解码预期运动时，神经假体设备的三维（3D）运动可以通过皮层神经元的活动来控制。先前的研究假设神经元保持固定的调谐特性，并且研究使用的受试者不知道其记录单元预测的运动。在这项研究中，受试者获得了大脑控制轨迹的实时视觉反馈。当用于大脑控制的运动时，细胞调节特性会发生变化。通过使用跟踪这些变化的控制算法，受试者使用比预期少得多的皮质单元进行长序列的 3D 运动。日常练习提高了这些单元的运动准确性和方向调整。
Three-dimensional (3D) movement of neuroprosthetic devices can be controlled by the activity of cortical neurons when appropriate algorithms are used to decode intended movement in real time. Previous studies assumed that neurons maintain fixed tuning properties, and the studies used subjects who were unaware of the movements predicted by their recorded units. In this study, subjects had real-time visual feedback of their brain-controlled trajectories. Cell tuning properties changed when used for brain-controlled movements. By using control algorithms that track these changes, subjects made long sequences of 3D movements using far fewer cortical units than expected. Daily practice improved movement accuracy and the directional tuning of these units.