Platelet aggregation and dense granule secretion in a colony of dogs with spontaneous hypertension.
Platelet aggregation and dense granule secretion in a colony of dogs with spontaneous hypertension.
复制标题
患有自发性高血压的狗群中的血小板聚集和致密颗粒分泌。
DOI：
10.1097/00004872-199210120-00009
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发表时间：
1992
影响因子：
4.9
通讯作者：
Padgett,GA
中科院分区：
文献类型：
--
作者：
Thomas,JS;McConnell,MF;Bell,TG;Padgett,GA
目的：由于犬遗传性原发性高血压已在以前报道的西伯利亚哈士奇犬的殖民地，我们测试了该模型的适用性，用于在研究中确定的血小板缺陷的人与原发性高血压。方法：血小板聚集和致密颗粒ATP分泌测定在犬原发性高血压和血压正常的对照犬。结果：血小板从高血压组表现出显着增加的聚集和分泌，响应于ADP的刺激。血小板活化因子、凝血酶、钙离子载体A23187或佛波醇肉豆蔻酸酯acetate.Conclusion：高血压犬血小板聚集和分泌反应增加，提示高血压犬存在与人类原发性高血压相似的缺陷，需要进一步研究。
Aim:Since canine hereditary essential hypertension has been previously reported in a colony of Siberian husky dogs, we tested the suitability of this model for use in studies on the platelet defect identified in humans with essential hypertension.Methods:Platelet aggregation and dense granule ATP secretion were measured in dogs with essential hypertension and normotensive control dogs.Results:The platelets from the hypertensive group showed significantly increased aggregation and secretion in response to stimulation with ADP. There was no significant increase in aggregation or secretion when platelets from hypertensive dogs were stimulated by platelet-activating factor, thrombin, calcium ionophore A23187 or phorbol myristate acetate.Conclusion:The increased aggregation and secretion responses in platelets from the hypertensive dogs suggest that a defect similar to that reported in humans with essential hypertension exists and that further investigation is warranted.