Comparison of integrated whole-body PET/MR and PET/CT: Is PET/MR alternative to PET/CT in routine clinical oncology?
Comparison of integrated whole-body PET/MR and PET/CT: Is PET/MR alternative to PET/CT in routine clinical oncology?
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DOI：
10.1007/s12149-015-1050-y
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发表时间：
2016-04-01
影响因子：
2.6
通讯作者：
Shishido, Fumio
中科院分区：
文献类型：
--
作者：
Ishii, Shirou;Shimao, Daisuke;Shishido, Fumio
比较全身PET/CT和集成PET/MR在总扫描持续时间方面的诊断准确性。男40例，女83例，平均年龄59.6岁;年龄范围20-83岁），确诊为原发性癌症且临床疑似转移性疾病，接受了全身18 F-FDG-PET/CT和18 F-FDG-PET/CT检查。在静脉内施用110-301 MBq放射性的18F-FDG后进行数据采集，并且在PET/CT数据采集后采集PET/MR数据。PET/CT和PET/MR采集的平均摄取时间分别为68.0 +/- A 8.0和98.0 +/- A 14 min。全身PET/CT和PET/MR成像的总扫描时间分别为20.0和25.0 min。重建的PET/CT和PET/MR数据在111/123（90.2%）例患者中检出333/355（93.8%）个常见病变。PET/CT和PET/MR单独检测分别为348/355和340/355个病变。两种技术的总体检测效率无显著差异（p = 0.08）。另一方面，观察到两种技术在检测肺部（p = 0.003）和脑脊髓（p = 0.007）病变方面存在显着差异。PET/CT共发现15个病灶，其中肺8个，淋巴结3个，骨2个，腹膜和肾上腺各1个。另一方面，7例（6例脑转移灶和1例骨转移灶）仅通过PET/MR确定，PET/MR是一种可行的全身成像方式，在检测脑转移灶方面可能优于PET/CT。为了进一步证明诊断实用性，这项技术需要进一步的临床验证。
To compare the diagnostic accuracy of whole-body PET/CT and integrated PET/MR in relation to the total scan time durations.One hundred and twenty-three (123) patients (40 males and 83 females; mean age 59.6 years; range 20-83 years) with confirmed primary cancer and clinical suspicion of metastatic disease underwent whole-body 18F-FDG-PET/CT and 18F-FDG-PET/MR. Data acquisition was done after intravenous administration of 110-301 MBq radioactivity of 18F-FDG, and PET/MR data were acquired after the PET/CT data acquisition. The mean uptake times for PET/CT and PET/MR acquisition were 68.0 +/- A 8.0 and 98.0 +/- A 14 min, respectively. Total scan time was 20.0 and 25.0 min for whole-body PET/CT and PET/MR imaging.The reconstructed PET/CT and PET/MR data detected 333/355 (93.8 %) common lesions in 111/123 (90.2 %) patients. PET/CT and PET/MR alone detected 348/355 and 340/355 lesions, respectively. No significant (p = 0.08) difference was observed for the overall detection efficiency between the two techniques. On the other hand, a significant difference was observed between the two techniques for the detection of lung (p = 0.003) and cerebrospinal (p = 0.007) lesions. The 15 lesions identified by PET/CT only included 8 lung, 3 lymph nodes, 2 bone, and 1 each of peritoneal and adrenal gland lesions. On the other hand, 7 (6 brain metastatic lesions and 1 bone lesion) were identified by PET/MR only.Integrated PET/MR is a feasible whole-body imaging modality and may score better than PET/CT for the detection of brain metastases. To further prove diagnostic utility, this technique requires further clinical validation.