Urethral circular smooth muscle in young and old women
Urethral circular smooth muscle in young and old women
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DOI：
10.1016/j.ajog.2008.03.009
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发表时间：
2008-05-01
影响因子：
9.8
通讯作者：
Morgan, Daniel M.
中科院分区：
文献类型：
--
作者：
Clobes, Amy;DeLancey, John O. L.;Morgan, Daniel M.
目的：本研究的目的是确定年轻女性和老年女性的尿道环形平滑肌 (CSM) 的厚度、纤维计数和密度是否存在差异。 研究设计：对 20-39 岁 (n = 12) 和 70-89 岁 (n = 16) 女性尸体的尿道中段半轴切片进行平滑肌 α 肌动蛋白染色。 CSM 在 0 度（耻骨侧）和 180 度（阴道侧）以及 45、90 和 135 度之间进行研究。测量CSM层宽度，计算纤维密度（纤维数/层宽度）。结果：20-39岁标本的尿道CSM密度比70-89岁标本高25%-50%。在 0、135 和 180 度处观察到差异。在年轻组中，在 135 度和 180 度时观察到纤维计数较高，CSM 层较薄，但不明显。 结论：老年女性 CSM 密度较低，这可能是与年龄相关的尿道闭合压力下降的原因。
OBJECTIVE: The purpose of this study was to determine whether thickness, fiber count, and density of urethral circular smooth muscle (CSM) differ in young and old women.STUDY DESIGN: Mid urethral hemiaxial sections from female cadavers aged 20-39 years (n = 12) and 70-89 years (n = 16) were stained for smooth muscle alpha actin. The CSM was studied at 0 degrees (pubic bone side) and 180 degrees (vaginal side) and in between at 45, 90, and 135 degrees. CSM layer width was measured fibers were counted density was calculated (fiber count/ layer width).RESULTS: Density of urethral CSM was 25%-50% higher in specimens aged 20-39 years, compared with those aged 70-89 years. Differences were observed at 0, 135, and 180 degrees. In the younger group, higher fiber counts were observed at 135 and 180 degrees, and the CSM layer was thinner but not significantly so.CONCLUSION: The density of CSM was lower among older women, which may account for age-related decline in urethral closure pressure.